MolNFT v1 · #126094 · protein

Crystal structure of yeast HSH49P in complex with CUS1P binding domain.

5LSL · Protein HSH49: “Crystal structure of yeast HSH49P in complex with CUS1P binding domain.”. X-ray diffraction, 5 pockets (best druggability 0.70). MolNFT v1 #126094 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 5LSL
Type: protein
Length: 564 residues
Chains: 8
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Protein HSH49; Cold sensitive U2 snrna suppressor 1
UniProt: Q99181, Q02554
Pockets: 5 · best druggability 0.70

Structure

x-ray diffraction · 3 distinct chains · 26% helix, 25% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C, D	Protein HSH49	protein	79	24% helix, 35% strand	Q99181
E, H, G	Cold sensitive U2 snrna suppressor 1	protein	62	27% helix, 18% strand	Q02554
F	Cold sensitive U2 snrna suppressor 1	protein	62	27% helix, 18% strand	Q02554

Pockets

5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	566	0.70	0.79	41	empty
2	135	0.50	0.80	20	empty
3	140	0.48	0.78	22	empty
4	59	0.31	0.75	11	empty
5	72	0.31	0.74	13	empty

Interfaces

11 interfaces between chains.

H–D · 1032 Å² buried · 18 hydrogen bonds · protein-protein
B–F · 989 Å² buried · 16 hydrogen bonds · protein-protein
A–E · 985 Å² buried · 16 hydrogen bonds · protein-protein
C–G · 984 Å² buried · 13 hydrogen bonds · protein-protein
A–G · 289 Å² buried · 5 hydrogen bonds · protein-protein

Compared structures

5LSL · Crystal structure of yeast Hsh49p in complex with Cus1p binding domain. · the same entry in another collection · chain G against G, TM-score 1.00
Q02554 · AlphaFold monomer V2.0 prediction for cold sensitive U2 snrna suppressor 1 (Q02554) · a predicted model of the same protein · chain H against A, TM-score 0.99
Q99181 · AlphaFold monomer V2.0 prediction for protein HSH49 (Q99181) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q99181
Every structure of UniProt Q02554
Elsewhere: RCSB PDB 5LSL · PDBe 5LSL · UniProt Q99181 · UniProt Q02554

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