MolNFT v1 · #126006 · protein

Crystal structure of PKC phosphorylation-mimicking mutant (S26E) annexin A2

5LPX: “Crystal structure of PKC phosphorylation-mimicking mutant (S26E) annexin A2”. X-ray diffraction, 1 ligand (CA), 3 pockets (best druggability 0.51). MolNFT v1 #126006 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 5LPX
Type: protein
Length: 311 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Annexin A2
UniProt: P07355
Ligands: CA
Pockets: 3 · best druggability 0.51

Structure

x-ray diffraction · 1 distinct chain · 74% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Annexin A2	protein	311	74% helix, 0% strand	P07355

Ligands and binding sites

CA · Calcium ion · metal · 5 copies · chains A
GOL · Glycerol · additive · 2 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	132	0.51	0.80	26	GOL
2	101	0.49	0.81	31	empty
3	64	0.30	0.75	11	empty

Compared structures

5LPX · Crystal structure of PKC phosphorylation-mimicking mutant (S26E) Annexin A2 · the same entry in another collection · chain A against A, TM-score 1.00
P07355 · AlphaFold monomer V2.0 prediction for annexin A2 (P07355) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P07355
Elsewhere: RCSB PDB 5LPX · PDBe 5LPX · UniProt P07355

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