MolNFT v1 · #125103 · protein
Structure of human anaplastic lymphoma kinase in complex with 2-[(1R)- 1-{[2-amino-5-(1,3-dimethyl-1H-pyrazol-4-YL)PYRIDIN-3-YL]OXY}ETHYL]- 4-fluoro-N,N-dimethylbenzamide
5KZ0: “Structure of human anaplastic lymphoma kinase in complex with 2-[(1R)…”. X-ray diffraction, 1 ligand (6YL). MolNFT v1 #125103 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5KZ0
- Type
- protein
- Length
- 293 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- Q9UM73
- Ligands
- 6YL
Structure
x-ray diffraction · 1 distinct chain.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 293 | — | Q9UM73 |
Ligands and binding sites
- 6YL · 2-[(1~{R})-1-[2-azanyl-5-(1,3-dimethylpyrazol-4-yl) pyridin-3-yl]oxyethyl]-4-fluoranyl-~{N},~{N}-dimethyl-benzamide · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 5KZ0 · Structure of Human Anaplastic Lymphoma Kinase in Complex With… · the same entry in another collection · chain A against A, TM-score 1.00
- Q9UM73 · AlphaFold monomer V2.0 prediction for ALK tyrosine kinase receptor (Q9UM73) · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9UM73
- Elsewhere: RCSB PDB 5KZ0 · PDBe 5KZ0 · UniProt Q9UM73
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