Structure of human anaplastic lymphoma kinase in complex with 2-[(1R)- 1-{[2-amino-5-(1,3-dimethyl-1H-pyrazol-4-YL)PYRIDIN-3-YL]OXY}ETHYL]- 4-fluoro-N,N-dimethylbenzamide

Structure

x-ray diffraction · 1 distinct chain · 41% helix, 16% strand (DSSP).

Ligands and binding sites

• 6YL · 2-[(1~{R})-1-[2-azanyl-5-(1,3-dimethylpyrazol-4-yl) pyridin-3-yl]oxyethyl]-4-fluoranyl-~{N},~{N}-dimethyl-benzamide · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Compared structures

• 5KZ0 · Structure of Human Anaplastic Lymphoma Kinase in Complex With… · the same entry in another collection · chain A against A, TM-score 1.00
• Q9UM73 · AlphaFold monomer V2.0 prediction for ALK tyrosine kinase receptor (Q9UM73) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt Q9UM73
• Elsewhere: RCSB PDB 5KZ0 · PDBe 5KZ0 · UniProt Q9UM73