MolNFT v1 · #12467 · protein
E. COLI alkaline phosphatase mutant (D153HD330N) zinc form
1KHN: “E. COLI alkaline phosphatase mutant (D153HD330N) zinc form”. X-ray diffraction, 1 ligand (ZN), 3 pockets (best druggability 0.79). MolNFT v1 #12467 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 1KHN
- Type
- protein
- Length
- 888 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Alkaline phosphatase
- EC
- 3.1.3.1
- UniProt
- P00634
- Ligands
- ZN
- Pockets
- 3 · best druggability 0.79
Structure
x-ray diffraction · 1 distinct chain · 30% helix, 21% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Alkaline phosphatase (EC 3.1.3.1) | protein | 444 | 30% helix, 21% strand | P00634 |
Ligands and binding sites
- ZN · Zinc ion · metal · 6 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 102 | 0.79 | 0.99 | 29 | empty |
| 2 | 135 | 0.38 | 0.73 | 21 | ZN |
| 3 | 139 | 0.37 | 0.73 | 24 | empty |
Interfaces
1 interface between chains.
- A–B · 3967 Ų buried · 76 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 disulfide (disulfide).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P00634
- Elsewhere: RCSB PDB 1KHN · PDBe 1KHN · UniProt P00634
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