MolNFT v1 · #124389 · protein

Structure of the human GLUN1/GLUN2A lbd in complex with GNE0723

5KDT: “Structure of the human GLUN1/GLUN2A lbd in complex with GNE0723”. X-ray diffraction, 1 ligand (6RV). MolNFT v1 #124389 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 5KDT
Type: protein
Length: 564 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
UniProt: Q12879, Q05586
Ligands: 6RV

Structure

x-ray diffraction · 2 distinct chains.

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	—	protein	279	—	Q12879
B	—	protein	285	—	Q05586

Ligands and binding sites

6RV · (1~{R},2~{R})-2-[7-[[5-chloranyl-3-(trifluoromethyl) pyrazol-1-yl]methyl]-5-oxidanylidene-2-(trifluoromethyl)-[1,3]thiazolo[3,2-a]pyrimidin-3-yl]cyclopropane-1-carbonitrile · ligand · chains A, B
ACT · Acetate ion · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

5KDT · Structure of the human GluN1/GluN2A LBD in complex with GNE0723 · the same entry in another collection · chain B against B, TM-score 1.00
Q12879 · AlphaFold monomer V2.0 prediction for glutamate receptor ionotropic, NMDA 2A (Q12879) · a predicted model of the same protein · chain A against A, TM-score 0.98
Q05586 · AlphaFold monomer V2.0 prediction for glutamate receptor ionotropic, NMDA 1 (Q05586) · a predicted model of the same protein · chain B against A, TM-score 0.96

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q12879
Every structure of UniProt Q05586
Elsewhere: RCSB PDB 5KDT · PDBe 5KDT · UniProt Q12879 · UniProt Q05586

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