MolNFT v1 · #124342 · protein
Crystal structure of the er-alpha ligand-binding domain (Y537S) in complex with an N-methyl, 2-chlorobenzyl obhs-N derivative
5KCE: “Crystal structure of the er-alpha ligand-binding domain (Y537S) in complex with an N-methyl, 2-chlorobenzyl…”. X-ray diffraction, 1 ligand (OB3). MolNFT v1 #124342 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5KCE
- Type
- protein
- Length
- 480 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- P03372, Q15596
- Ligands
- OB3
Structure
x-ray diffraction · 4 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 223 | — | P03372 |
| B | — | protein | 239 | — | P03372 |
| C | — | protein | 10 | — | Q15596 |
| D | — | protein | 8 | — | Q15596 |
Ligands and binding sites
- OB3 · (1S,2R,4S)-N-(2-chlorophenyl)-5,6-bis(4-hydroxyphenyl)-N-methyl-7-oxabicyclo[2.2.1]hept-5-ene-2-sulfonamide · ligand · 3 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 5KCE · Crystal Structure of the ER-alpha Ligand-binding Domain (Y537S) in Complex with an… · the same entry in another collection · chain A against A, TM-score 1.00
- P03372 · AlphaFold monomer V2.0 prediction for estrogen receptor (P03372) · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P03372
- Every structure of UniProt Q15596
- Elsewhere: RCSB PDB 5KCE · PDBe 5KCE · UniProt P03372 · UniProt Q15596
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