MolNFT v1 · #123858 · protein
Structure of the unliganded form of the proprotein convertase furin in presence of edta.
5JXI: “Structure of the unliganded form of the proprotein convertase furin in presence of edta.”. X-ray diffraction, 3 ligands (NA, CA, CL), 3 pockets (best druggability 0.45). MolNFT v1 #123858 on GenesisL1: 3D structure, binding sites…
- PDB
- 5JXI
- Type
- protein
- Length
- 472 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Furin
- EC
- 3.4.21.75
- UniProt
- P09958
- Ligands
- NA, CA, CL
- Pockets
- 3 · best druggability 0.45
Structure
x-ray diffraction · 1 distinct chain · 20% helix, 27% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Furin (EC 3.4.21.75) | protein | 472 | 20% helix, 27% strand | P09958 |
Ligands and binding sites
- NA · Sodium ion · metal · 7 copies · chains A
- CA · Calcium ion · metal · chains A
- CL · Chloride ion · ion · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 116 | 0.45 | 0.78 | 14 | empty |
| 2 | 104 | 0.35 | 0.74 | 21 | NA |
| 3 | 76 | 0.30 | 0.73 | 24 | empty |
Modifications
Observed in the structure: 3 disulfide (disulfide).
Compared structures
- 5JXI · Structure of the unliganded form of the proprotein convertase furin in presence of EDTA. · the same entry in another collection · chain A against A, TM-score 1.00
- P09958 · AlphaFold monomer V2.0 prediction for furin (P09958) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P09958
- Elsewhere: RCSB PDB 5JXI · PDBe 5JXI · UniProt P09958
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