Research workbench
Structure of the unliganded form of the proprotein convertase furin in presence of edta.
Analyse Structure of the unliganded form of the proprotein convertase furin in presence… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5JXI
- Type
- protein
- Length
- 472 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Furin
- EC
- 3.4.21.75
- UniProt
- P09958
- Ligands
- NA, CA, CL
- Pockets
- 3 · best druggability 0.45
Structure
x-ray diffraction · 1 distinct chain · 20% helix, 27% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Furin (EC 3.4.21.75) | protein | 472 | 20% helix, 27% strand | P09958 |
Ligands and binding sites
- NA · Sodium ion · metal · 7 copies · chains A
- CA · Calcium ion · metal · chains A
- CL · Chloride ion · ion · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 116 | 0.45 | 0.78 | 14 | empty |
| 2 | 104 | 0.35 | 0.74 | 21 | NA |
| 3 | 76 | 0.30 | 0.73 | 24 | empty |
Modifications
Observed in the structure: 3 disulfide (disulfide).
Compared structures
- 5JXI · Structure of the unliganded form of the proprotein convertase furin in presence of EDTA. · the same entry in another collection · chain A against A, TM-score 1.00
- P09958 · AlphaFold monomer V2.0 prediction for furin (P09958) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P09958
- Elsewhere: RCSB PDB 5JXI · PDBe 5JXI · UniProt P09958
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