MolNFT v1 · #122790 · protein
Crystal structure of a chimeric KV7.2 - KV7.3 proximal C-terminal domain in complex with calmodulin
5J03 · Potassium voltage-gated channel subfamily kqt member 3…: “Crystal structure of a chimeric KV7.2 - KV7.3 proximal C-terminal domain in complex with calmodulin”. X-ray diffraction, 1 ligand (CA), 3 pockets (best druggability 0.56).…
- PDB
- 5J03
- Type
- protein
- Length
- 219 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Potassium voltage-gated channel subfamily kqt member 3, potassium voltage-gated channel…
- UniProt
- O43525, O43526, P62158
- Ligands
- CA
- Pockets
- 3 · best druggability 0.56
Structure
x-ray diffraction · 2 distinct chains · 64% helix, 5% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Potassium voltage-gated channel subfamily kqt member 3, potassium voltage-gated channel subfamily kqt member 2 | protein | 73 | 73% helix, 0% strand | O43525, O43526 |
| B | Calmodulin | protein | 146 | 60% helix, 7% strand | P62158 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 149 | 0.56 | 0.82 | 25 | empty |
| 2 | 125 | 0.49 | 0.79 | 19 | empty |
| 3 | 61 | 0.33 | 0.76 | 17 | empty |
Interfaces
1 interface between chains.
- A–B · 2250 Ų buried · 28 hydrogen bonds · protein-protein
Compared structures
- 5J03 · Crystal Structure of a chimeric Kv7.2 - Kv7.3 proximal C-terminal Domain in Complex with… · the same entry in another collection · chain A against A, TM-score 1.00
- O43526 · AlphaFold monomer V2.0 prediction for potassium voltage-gated channel subfamily kqt… · a predicted model of the same protein · chain A against A, TM-score 0.85
- O43525 · AlphaFold monomer V2.0 prediction for potassium voltage-gated channel subfamily kqt… · a predicted model of the same protein · chain A against A, TM-score 0.81
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O43525
- Every structure of UniProt O43526
- Every structure of UniProt P62158
- Elsewhere: RCSB PDB 5J03 · PDBe 5J03 · UniProt O43525 · UniProt O43526 · UniProt P62158
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