MolNFT v1 · #122725 · protein

Crystal structure of the signaling protein complex 4

5IXX · ALR2278 protein: “Crystal structure of the signaling protein complex 4”. X-ray diffraction, 2 ligands (HEM, 6EX), 3 pockets (best druggability 0.83). MolNFT v1 #122725 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 5IXX
Type: protein
Length: 364 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: ALR2278 protein
UniProt: Q8YUQ7
Ligands: HEM, 6EX
Pockets: 3 · best druggability 0.83

Structure

x-ray diffraction · 1 distinct chain · 54% helix, 16% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	ALR2278 protein	protein	182	54% helix, 16% strand	Q8YUQ7

Ligands and binding sites

HEM · Protoporphyrin IX containing Fe · ligand · 2 copies · chains A, B
6EX · 1-(1H-imidazol-1-yl)ethan-1-one · ligand · 2 copies · chains A, B
MLI · Malonate ion · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	405	0.83	0.91	58	HEM, 6EX
2	674	0.83	0.87	95	HEM, 6EX
3	263	0.61	0.79	45	MLI

Interfaces

1 interface between chains.

A–B · 1086 Å² buried · 5 hydrogen bonds · protein-protein

Compared structures

5IXX · Crystal structure of the signaling protein complex 4 · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8YUQ7
Elsewhere: RCSB PDB 5IXX · PDBe 5IXX · UniProt Q8YUQ7

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.