MolNFT v1 · #122706 · protein
Structure of human JAK1 FERM/SH2 in complex with ifn lambda receptor
5IXD · Tyrosine-protein kinase JAK1: “Structure of human JAK1 FERM/SH2 in complex with ifn lambda receptor”. X-ray diffraction, 7 pockets (best druggability 0.80). MolNFT v1 #122706 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 5IXD
- Type
- protein
- Length
- 441 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Tyrosine-protein kinase JAK1; Interferon lambda receptor 1
- EC
- 2.7.10.2
- UniProt
- P23458, Q8IU57
- Pockets
- 7 · best druggability 0.80
Structure
x-ray diffraction · 2 distinct chains · 36% helix, 19% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Tyrosine-protein kinase JAK1 (EC 2.7.10.2) | protein | 420 | 37% helix, 20% strand | P23458 |
| B | Interferon lambda receptor 1 | protein | 21 | 29% helix, 0% strand | Q8IU57 |
Ligands and binding sites
- CIT · Citric acid · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
7 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 463 | 0.80 | 0.88 | 55 | empty |
| 2 | 351 | 0.66 | 0.80 | 27 | empty |
| 3 | 193 | 0.48 | 0.75 | 25 | empty |
| 4 | 74 | 0.43 | 0.81 | 19 | empty |
| 5 | 103 | 0.36 | 0.74 | 21 | empty |
Interfaces
1 interface between chains.
- A–B · 1056 Ų buried · 16 hydrogen bonds · protein-protein
Compared structures
- 5IXD · Structure of human JAK1 FERM/SH2 in complex with IFN lambda receptor · the same entry in another collection · chain A against A, TM-score 1.00
- Q8IU57 · AlphaFold monomer V2.0 prediction for interferon lambda receptor 1 (Q8IU57) · a predicted model of the same protein · chain B against A, TM-score 0.14
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P23458
- Every structure of UniProt Q8IU57
- Elsewhere: RCSB PDB 5IXD · PDBe 5IXD · UniProt P23458 · UniProt Q8IU57
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