MolNFT v1 · #122038 · protein
Cryo-EM structure of GLUA2/3 AMPA receptor heterotetramer (model II)
5IDF · Glutamate receptor 2: “Cryo-EM structure of GLUA2/3 AMPA receptor heterotetramer (model II)”. Electron microscopy, 20 pockets (best druggability 0.68). MolNFT v1 #122038 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5IDF
- Type
- protein
- Length
- 2,947 residues
- Chains
- 4
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Glutamate receptor 2; Glutamate receptor 3
- UniProt
- P19491, P19492
- Pockets
- 20 · best druggability 0.68
Structure
electron microscopy · 4 distinct chains · 43% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Glutamate receptor 2 | protein | 741 | 43% helix, 18% strand | P19491 |
| B | Glutamate receptor 3 | protein | 734 | 43% helix, 18% strand | P19492 |
| C | Glutamate receptor 2 | protein | 738 | 43% helix, 18% strand | P19491 |
| D | Glutamate receptor 3 | protein | 734 | 43% helix, 18% strand | P19492 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 720 | 0.68 | 0.77 | 105 | empty |
| 2 | 937 | 0.68 | 0.75 | 83 | empty |
| 3 | 451 | 0.68 | 0.80 | 68 | empty |
| 4 | 594 | 0.67 | 0.78 | 99 | empty |
| 5 | 509 | 0.67 | 0.79 | 92 | empty |
Interfaces
4 interfaces between chains.
- C–D · 499 Ų buried · 1 hydrogen bond · protein-protein
- A–D · 467 Ų buried · 1 hydrogen bond · protein-protein
- A–B · 315 Ų buried · 0 hydrogen bonds · protein-protein
- B–C · 265 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 5IDF · Cryo-EM structure of GluA2/3 AMPA receptor heterotetramer (model II) · the same entry in another collection · chain A against A, TM-score 1.00
- P19492 · AlphaFold monomer V2.0 prediction for glutamate receptor 3 (P19492) · a predicted model of the same protein · chain B against A, TM-score 0.67
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P19491
- Every structure of UniProt P19492
- Elsewhere: RCSB PDB 5IDF · PDBe 5IDF · UniProt P19491 · UniProt P19492
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