MolNFT v1 · #121410 · protein
Structure of candida albicans trehalose-6-phosphate synthase in complex with udp and glucose-6-phosphate
5HUU · ALPHA,ALPHA-trehalose-phosphate synthase [udp-forming]: “Structure of candida albicans trehalose-6-phosphate synthase in complex with udp and glucose-6-phosphate”. X-ray diffraction, 2 ligands (UDP, G6P), 11 pockets (best…
- PDB
- 5HUU
- Type
- protein
- Length
- 919 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- ALPHA,ALPHA-trehalose-phosphate synthase [udp-forming]
- EC
- 2.4.1.15
- UniProt
- Q92410
- Ligands
- UDP, G6P
- Pockets
- 11 · best druggability 0.77
Structure
x-ray diffraction · 2 distinct chains · 48% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | ALPHA,ALPHA-trehalose-phosphate synthase [udp-forming] (EC 2.4.1.15) | protein | 469 | 49% helix, 19% strand | Q92410 |
| B | ALPHA,ALPHA-trehalose-phosphate synthase [udp-forming] (EC 2.4.1.15) | protein | 450 | 48% helix, 17% strand | Q92410 |
Ligands and binding sites
- UDP · Uridine-5'-diphosphate · ligand · 2 copies · chains A, B
- G6P · 6-O-phosphono-alpha-D-glucopyranose · sugar · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
11 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 865 | 0.77 | 0.80 | 56 | UDP, G6P |
| 2 | 843 | 0.76 | 0.79 | 55 | UDP, G6P |
| 3 | 751 | 0.71 | 0.77 | 70 | empty |
| 4 | 133 | 0.48 | 0.79 | 24 | empty |
| 5 | 102 | 0.46 | 0.80 | 23 | empty |
Interfaces
1 interface between chains.
- A–B · 1148 Ų buried · 21 hydrogen bonds · protein-protein
Compared structures
- 5HUU · Structure of Candida albicans trehalose-6-phosphate synthase in complex with UDP and… · the same entry in another collection · chain A against A, TM-score 1.00
- Q92410 · AlphaFold monomer V2.0 prediction for ALPHA,ALPHA-trehalose-phosphate synthase… · a predicted model of the same protein · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q92410
- Elsewhere: RCSB PDB 5HUU · PDBe 5HUU · UniProt Q92410
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.