MolNFT v1 · #120283 · protein

WD40 domain of human and-1

5GVA · Wd repeat and hmg-box DNA-binding protein 1: “WD40 domain of human and-1”. X-ray diffraction, 3 pockets (best druggability 0.80). MolNFT v1 #120283 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 5GVA
Type: protein
Length: 305 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Wd repeat and hmg-box DNA-binding protein 1
UniProt: O75717
Pockets: 3 · best druggability 0.80

Structure

x-ray diffraction · 1 distinct chain · 1% helix, 51% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Wd repeat and hmg-box DNA-binding protein 1	protein	305	1% helix, 51% strand	O75717

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	648	0.80	0.85	41	empty
2	62	0.48	0.85	18	empty
3	187	0.47	0.75	25	empty

Modifications

Observed in the structure: 1 disulfide (disulfide).

Compared structures

5GVA · WD40 domain of human AND-1 · the same entry in another collection · chain A against A, TM-score 1.00
O75717 · AlphaFold monomer V2.0 prediction for wd repeat and hmg-box DNA- binding protein 1… · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O75717
Elsewhere: RCSB PDB 5GVA · PDBe 5GVA · UniProt O75717

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