MolNFT v1 · #120058 · protein
Structure of psd-95/MAP1A complex reveals unique target recognition mode of maguk gk domain
5GNV · Disks large homolog 4: “Structure of psd-95/MAP1A complex reveals unique target recognition mode of maguk gk domain”. X-ray diffraction, 1 ligand (SO4), 1 pocket (best druggability 0.50). MolNFT v1 #120058 on GenesisL1: 3D…
- PDB
- 5GNV
- Type
- protein
- Length
- 200 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Disks large homolog 4; Microtubule-associated protein 1A
- UniProt
- P31016, Q9QYR6
- Ligands
- SO4
- Pockets
- 1 · best druggability 0.50
Structure
x-ray diffraction · 2 distinct chains · 45% helix, 19% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Disks large homolog 4 | protein | 181 | 46% helix, 20% strand | P31016 |
| B | Microtubule-associated protein 1A | protein | 19 | 37% helix, 0% strand | Q9QYR6 |
Ligands and binding sites
- SO4 · Sulfate ion · ion · 2 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 251 | 0.50 | 0.75 | 33 | empty |
Interfaces
1 interface between chains.
- A–B · 638 Ų buried · 14 hydrogen bonds · protein-protein
Compared structures
- 5GNV · Structure of PSD-95/MAP1A complex reveals unique target recognition mode of MAGUK GK… · the same entry in another collection · chain A against A, TM-score 1.00
- P31016 · AlphaFold monomer V2.0 prediction for disks large homolog 4 (P31016) · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P31016
- Every structure of UniProt Q9QYR6
- Elsewhere: RCSB PDB 5GNV · PDBe 5GNV · UniProt P31016 · UniProt Q9QYR6
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