UniProt P31016

Disks large homolog 4 (P31016)

Disks large homolog 4 (UniProt P31016): 76 experimental structures and 1 predicted model on GenesisL1, 5 ligands bound, 25 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.

UniProt: P31016
Protein: Disks large homolog 4
Experimental structures: 76
Predicted models: 1
Ligands: 5
Pockets: 25 · 4 records with a druggable one

Structures

77 records of P31016 in the MolNFT archive: 76 experimental, 1 predicted.

Entry	Title	Method	Chains	Ligands	Pockets
1BE9	The third PDZ domain from the synaptic protein psd-95 in complex with a C-terminal peptide derived…	x-ray diffraction	A	—	—
1BE9	The third PDZ domain from the synaptic protein psd-95 in complex with a C-terminal peptide derived…	x-ray diffraction	A	—	—
1BFE	The third PDZ domain from the synaptic protein psd-95	x-ray diffraction	A	—	—
1BFE	The third PDZ domain from the synaptic protein psd-95	x-ray diffraction	A	—	—
1IU0	The first PDZ domain of PSD-95	solution nmr	A	—	—
1IU0	The first PDZ domain of psd-95	solution nmr	A	—	—
1IU2	The first PDZ domain of PSD-95	solution nmr	A	—	—
1IU2	The first PDZ domain of psd-95	solution nmr	A	—	—
1JXM	Crystal structure of the gmp bound SH3-hook-gk fragment of psd-95	x-ray diffraction	A	—	—
1JXM	Crystal structure of the gmp bound SH3-hook-gk fragment of psd-95	x-ray diffraction	A	—	—
1JXO	Crystal Structure of the SH3-HOOK-GK Fragment of PSD-95	x-ray diffraction	A, B	—	—
1JXO	Crystal structure of the SH3-hook-gk fragment of psd-95	x-ray diffraction	A, B	—	—
1KJW	SH3-Guanylate Kinase Module from PSD-95	x-ray diffraction	A	—	—
1KJW	SH3-guanylate kinase module from psd-95	x-ray diffraction	A	—	—
1QLC	Solution structure of the second PDZ domain of Postsynaptic Density-95	solution nmr	A	—	—
1QLC	Solution structure of the second PDZ domain of postsynaptic density-95	solution nmr	A	—	—
1RGR	Cyclic Peptides Targeting PDZ Domains of PSD-95: Structural Basis for Enhanced Affinity and…	solution nmr	A	—	—
1RGR	Cyclic peptides targeting PDZ domains of psd-95: structural basis for enhanced affinity and…	solution nmr	A	—	—
1TP3	PDZ3 domain of PSD-95 protein complexed with KKETPV peptide ligand	x-ray diffraction	A	—	—
1TP3	PDZ3 domain of psd-95 protein complexed with kketpv peptide ligand	x-ray diffraction	A	—	—
1TP5	Crystal structure of PDZ3 domain of PSD-95 protein complexed with a peptide ligand KKETWV	x-ray diffraction	A	—	—
1TP5	Crystal structure of PDZ3 domain of psd-95 protein complexed with a peptide ligand kketwv	x-ray diffraction	A	—	—
1TQ3	Higher resolution crystal structure of the third PDZ domain of post synaptic PSD-95 protein	x-ray diffraction	A	—	—
1TQ3	Higher resolution crystal structure of the third PDZ domain of post synaptic psd-95 protein	x-ray diffraction	A	—	—
2KA9	Solution structure of PSD-95 PDZ12 complexed with cypin peptide	solution nmr	A	—	—
2KA9	Solution structure of psd-95 PDZ12 complexed with cypin peptide	solution nmr	A	—	—
2MHO	Solution State Structure PSD-95 PDZ1 with 5HT2C Receptor peptide	solution nmr	A	—	—
2MHO	Solution state structure psd-95 PDZ1 with 5HT2C receptor peptide	solution nmr	A	—	—
2XKX	Single particle analysis of PSD-95 in negative stain	electron microscopy, solution scattering	A, B	—	—
2XKX	Single particle analysis of psd-95 in negative stain	electron microscopy; solution scattering	A, B	—	—
3GSL	Crystal structure of PSD-95 tandem PDZ domains 1 and 2	x-ray diffraction	A, B	—	—
3GSL	Crystal structure of psd-95 tandem PDZ domains 1 and 2	x-ray diffraction	A, B	—	—
3WP0	Crystal structure of Dlg GK in complex with a phosphor-Lgl2 peptide	x-ray diffraction	A	—	—
3WP0	Crystal structure of dlg gk in complex with a phosphor-LGL2 peptide	x-ray diffraction	A	—	—
3WP1	Phosphorylation-dependent interaction between tumor suppressors Dlg and Lgl	x-ray diffraction	B	—	—
3WP1	Phosphorylation-dependent interaction between tumor suppressors dlg and lgl	x-ray diffraction	B	—	—
5D13	Third PDZ domain (PDZ3) of psd-95 complexed with cfmoc-kketev peptide	x-ray diffraction	A, B, C, D	—	—
5GNV	Structure of PSD-95/MAP1A complex reveals unique target recognition mode of MAGUK GK domain	x-ray diffraction	A	SO4	—
5GNV	Structure of psd-95/MAP1A complex reveals unique target recognition mode of maguk gk domain	x-ray diffraction	A	—	—
5HDY	The third PDZ domain from the synaptic protein PSD-95	x-ray diffraction	A	—	—
5HDY	The third PDZ domain from the synaptic protein psd-95	x-ray diffraction	A	—	—
5HEB	The third PDZ domain from the synaptic protein PSD-95 in complex with a C-terminal peptide derived…	x-ray diffraction	A	—	—
5HEB	The third PDZ domain from the synaptic protein psd-95 in complex with a C-terminal peptide derived…	x-ray diffraction	A	—	—
5HED	The third PDZ domain from the synaptic protein PSD-95 in complex with a mutant C-terminal peptide…	x-ray diffraction	A	—	—
5HED	The third PDZ domain from the synaptic protein psd-95 in complex with a mutant C-terminal peptide…	x-ray diffraction	A	—	—
5HET	The third PDZ domain from the synaptic protein PSD-95 (G330T mutant)	x-ray diffraction	A	—	—
5HET	The third PDZ domain from the synaptic protein psd-95 (G330T mutant)	x-ray diffraction	A	—	—
5HEY	The third PDZ domain from the synaptic protein PSD-95 (G330T mutant) in complex with a C-terminal…	x-ray diffraction	A	—	—
5HEY	The third PDZ domain from the synaptic protein psd-95 (G330T mutant) in complex with a C-terminal…	x-ray diffraction	A	—	—
5HF1	The third PDZ domain from the synaptic protein PSD-95 (G330T mutant) in complex with a mutant…	x-ray diffraction	A	—	—
5HF1	The third PDZ domain from the synaptic protein psd-95 (G330T mutant) in complex with a mutant…	x-ray diffraction	A	—	—
5HF4	The third PDZ domain from the synaptic protein PSD-95 (H372A mutant)	x-ray diffraction	A	—	—
5HF4	The third PDZ domain from the synaptic protein psd-95 (H372A mutant)	x-ray diffraction	A	—	—
5HFB	The third PDZ domain from the synaptic protein PSD-95 (H372A mutant) in complex with a C-terminal…	x-ray diffraction	A	—	—
5HFB	The third PDZ domain from the synaptic protein psd-95 (H372A mutant) in complex with a C-terminal…	x-ray diffraction	A	—	—
5HFC	The third PDZ domain from the synaptic protein PSD-95 (H372A mutant) in complex with a mutant…	x-ray diffraction	A	—	—
5HFC	The third PDZ domain from the synaptic protein psd-95 (H372A mutant) in complex with a mutant…	x-ray diffraction	A	—	—
5HFD	The third PDZ domain from the synaptic protein PSD-95 (G330T, H372A double mutant)	x-ray diffraction	A	—	—
5HFD	The third PDZ domain from the synaptic protein psd-95 (G330T, H372A double mutant)	x-ray diffraction	A	—	—
5HFE	The third PDZ domain from the synaptic protein PSD-95 (G330T, H372A double mutant) in complex with…	x-ray diffraction	A	—	—

17 records more on the page itself.

Ligands

CHT · Choline ion · in 2 records
CL · Chloride ion · in 2 records
ACE · Acetyl group · in 1 record
NH2 · Amino group · in 1 record
SO4 · Sulfate ion · in 1 record

Experiment against prediction

3WP1 chain B against the predicted model P31016: TM-score 0.99, RMSD 0.57 Å
3WP1 chain B against the predicted model P31016: TM-score 0.99, RMSD 0.57 Å
3WP0 chain A against the predicted model P31016: TM-score 0.99, RMSD 0.59 Å
3WP0 chain A against the predicted model P31016: TM-score 0.99, RMSD 0.59 Å
5GNV chain A against the predicted model P31016: TM-score 0.98, RMSD 0.64 Å
5GNV chain A against the predicted model P31016: TM-score 0.98, RMSD 0.64 Å
7F7G chain B against the predicted model P31016: TM-score 0.98, RMSD 1.06 Å
7F7G chain B against the predicted model P31016: TM-score 0.98, RMSD 1.06 Å
1JXM chain A against the predicted model P31016: TM-score 0.98, RMSD 1.03 Å
1JXM chain A against the predicted model P31016: TM-score 0.98, RMSD 1.03 Å

Elsewhere

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