MolNFT v1 · #119944 · protein
The crystal structure of the cps-6 H148A/F122A
5GKC · Endonuclease G, mitochondrial: “The crystal structure of the cps-6 H148A/F122A”. X-ray diffraction, 5 pockets (best druggability 0.71). MolNFT v1 #119944 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5GKC
- Type
- protein
- Length
- 481 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Endonuclease G, mitochondrial
- EC
- 3.1.30.-
- UniProt
- Q95NM6
- Pockets
- 5 · best druggability 0.71
Structure
x-ray diffraction · 2 distinct chains · 25% helix, 31% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Endonuclease G, mitochondrial (EC 3.1.30.-) | protein | 238 | 26% helix, 32% strand | Q95NM6 |
| B | Endonuclease G, mitochondrial (EC 3.1.30.-) | protein | 243 | 25% helix, 31% strand | Q95NM6 |
Pockets
5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 207 | 0.71 | 0.87 | 42 | empty |
| 2 | 109 | 0.42 | 0.77 | 18 | empty |
| 3 | 73 | 0.36 | 0.77 | 17 | empty |
| 4 | 98 | 0.33 | 0.73 | 18 | empty |
| 5 | 69 | 0.28 | 0.73 | 12 | empty |
Interfaces
1 interface between chains.
- A–B · 1535 Ų buried · 23 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q95NM6
- Elsewhere: RCSB PDB 5GKC · PDBe 5GKC · UniProt Q95NM6
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