MolNFT v1 · #11993 · protein
Structure of the insulin-like growth factor 1 receptor kinase
1K3A: “Structure of the insulin-like growth factor 1 receptor kinase”. X-ray diffraction, 1 ligand (ACP), 2 pockets (best druggability 0.60). MolNFT v1 #11993 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 1K3A
- Type
- protein
- Length
- 299 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Insulin-like growth factor 1 receptor; Insulin receptor substrate 1
- EC
- 2.7.1.112
- UniProt
- P08069, P35568
- Ligands
- ACP
- Pockets
- 2 · best druggability 0.60
Structure
x-ray diffraction · 2 distinct chains · 36% helix, 22% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Insulin-like growth factor 1 receptor (EC 2.7.1.112) | protein | 291 | 37% helix, 22% strand | P08069 |
| B | Insulin receptor substrate 1 | protein | 8 | 0% helix, 50% strand | P35568 |
Ligands and binding sites
- ACP · Phosphomethylphosphonic acid adenylate ester · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 368 | 0.60 | 0.77 | 42 | ACP |
| 2 | 51 | 0.24 | 0.72 | 13 | empty |
Interfaces
1 interface between chains.
- A–B · 637 Ų buried · 12 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 3 modified (phosphorylation).
Compared structures
- 1K3A · Structure of the Insulin-like Growth Factor 1 Receptor Kinase · the same entry in another collection · chain A against A, TM-score 1.00
- P08069 · AlphaFold monomer V2.0 prediction for insulin-like growth factor 1 receptor (P08069) · a predicted model of the same protein · chain A against A, TM-score 0.93
- P35568 · AlphaFold monomer V2.0 prediction for insulin receptor substrate 1 (P35568) · a predicted model of the same protein · chain B against A, TM-score 0.45
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P08069
- Every structure of UniProt P35568
- Elsewhere: RCSB PDB 1K3A · PDBe 1K3A · UniProt P08069 · UniProt P35568
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