MolNFT v1 · #119873 · protein
Dead-box RNA helicase
5GI4 · ATP-dependent RNA helicase dead: “Dead-box RNA helicase”. X-ray diffraction, 5 pockets (best druggability 0.43). MolNFT v1 #119873 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5GI4
- Type
- protein
- Length
- 445 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- ATP-dependent RNA helicase dead
- EC
- 3.6.4.13
- UniProt
- P0A9P6
- Pockets
- 5 · best druggability 0.43
Structure
x-ray diffraction · 2 distinct chains · 46% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | ATP-dependent RNA helicase dead (EC 3.6.4.13) | protein | 218 | 47% helix, 15% strand | P0A9P6 |
| B | ATP-dependent RNA helicase dead (EC 3.6.4.13) | protein | 227 | 44% helix, 15% strand | P0A9P6 |
Pockets
5 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 132 | 0.43 | 0.76 | 22 | empty |
| 2 | 91 | 0.37 | 0.76 | 19 | empty |
| 3 | 82 | 0.34 | 0.75 | 20 | empty |
| 4 | 77 | 0.30 | 0.73 | 15 | empty |
| 5 | 61 | 0.30 | 0.74 | 16 | empty |
Interfaces
1 interface between chains.
- A–B · 1918 Ų buried · 18 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P0A9P6
- Elsewhere: RCSB PDB 5GI4 · PDBe 5GI4 · UniProt P0A9P6
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