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Dead-box RNA helicase

Analyse Dead-box RNA helicase in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 5GI4
Type: protein
Length: 445 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: ATP-dependent RNA helicase dead
EC: 3.6.4.13
UniProt: P0A9P6
Pockets: 5 · best druggability 0.43

Structure

x-ray diffraction · 2 distinct chains · 46% helix, 15% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	ATP-dependent RNA helicase dead (EC 3.6.4.13)	protein	218	47% helix, 15% strand	P0A9P6
B	ATP-dependent RNA helicase dead (EC 3.6.4.13)	protein	227	44% helix, 15% strand	P0A9P6

Pockets

5 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	132	0.43	0.76	22	empty
2	91	0.37	0.76	19	empty
3	82	0.34	0.75	20	empty
4	77	0.30	0.73	15	empty
5	61	0.30	0.74	16	empty

Interfaces

1 interface between chains.

A–B · 1918 Å² buried · 18 hydrogen bonds · protein-protein

Compared structures

5GI4 · DEAD-box RNA helicase · the same entry in another collection · chain A against A, TM-score 1.00
P0A9P6 · AlphaFold monomer V2.0 prediction for ATP-dependent RNA helicase dead (P0A9P6) · a predicted model of the same protein · chain B against A, TM-score 0.96

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P0A9P6
Elsewhere: RCSB PDB 5GI4 · PDBe 5GI4 · UniProt P0A9P6

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