MolNFT v1 · #119463 · protein

Wnt modulator kremen crystal form I at 1.90A

5FWS · Kremen protein 1: “Wnt modulator kremen crystal form I at 1.90A”. X-ray diffraction, 3 ligands (NAG, CA, SO4), 2 pockets (best druggability 0.64). MolNFT v1 #119463 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 5FWS
Type: protein
Length: 288 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Kremen protein 1
UniProt: Q96MU8
Ligands: NAG, CA, SO4
Pockets: 2 · best druggability 0.64

Structure

x-ray diffraction · 1 distinct chain · 7% helix, 36% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Kremen protein 1	protein	288	7% helix, 36% strand	Q96MU8

Ligands and binding sites

NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 3 copies · chains A
CA · Calcium ion · metal · chains A
SO4 · Sulfate ion · ion · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	103	0.64	0.89	28	empty
2	82	0.31	0.73	19	empty

Modifications

Observed in the structure: 8 disulfide, 3 glycan (disulfide, N-glycosylation).

Compared structures

5FWS · Wnt modulator Kremen crystal form I at 1.90A · the same entry in another collection · chain A against A, TM-score 1.00
Q96MU8 · AlphaFold monomer V2.0 prediction for kremen protein 1 (Q96MU8) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q96MU8
Elsewhere: RCSB PDB 5FWS · PDBe 5FWS · UniProt Q96MU8

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