MolNFT v1 · #119449 · protein
Crystal structure of mus musculus protein arginine methyltransferase 2 with CP2
5FWD · Protein arginine N-methyltransferase 2: “Crystal structure of mus musculus protein arginine methyltransferase 2 with CP2”. X-ray diffraction, 3 ligands (GJV, CA, CL), 1 pocket (best druggability 0.73). MolNFT v1 #119449 on…
- PDB
- 5FWD
- Type
- protein
- Length
- 339 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Protein arginine N-methyltransferase 2
- EC
- 2.1.1.125
- UniProt
- Q3UKX1
- Ligands
- GJV, CA, CL
- Pockets
- 1 · best druggability 0.73
Structure
x-ray diffraction · 1 distinct chain · 26% helix, 36% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Protein arginine N-methyltransferase 2 (EC 2.1.1.125) | protein | 339 | 26% helix, 36% strand | Q3UKX1 |
Ligands and binding sites
- GJV · 9-(7-{[amino(iminio)methyl]amino}-5,6,7-trideoxy-beta-D-ribo-heptofuranosyl)-9H-purin-6-amine · ligand · chains A
- CA · Calcium ion · metal · 2 copies · chains A
- CL · Chloride ion · ion · chains A
- EDO · 1,2-ethanediol · additive · 6 copies · chains A
- PG4 · Tetraethylene glycol · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 346 | 0.73 | 0.85 | 46 | GJV, EDO |
Compared structures
- 5FWD · Crystal Structure of Mus musculus Protein Arginine Methyltransferase 2 with CP2 · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q3UKX1
- Elsewhere: RCSB PDB 5FWD · PDBe 5FWD · UniProt Q3UKX1
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