MolNFT v1 · #118896 · protein
Crystal structure of the bromodomain of human BRPF1 in complex with H4K5ACK8AC histone peptide
5FFW · Peregrin: “Crystal structure of the bromodomain of human BRPF1 in complex with H4K5ACK8AC histone peptide”. X-ray diffraction, 1 pocket (best druggability 0.56). MolNFT v1 #118896 on GenesisL1: 3D structure, binding sites and…
- PDB
- 5FFW
- Type
- protein
- Length
- 231 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Peregrin; Histone H4
- UniProt
- P55201, Q0VAS5
- Pockets
- 1 · best druggability 0.56
Structure
x-ray diffraction · 3 distinct chains · 60% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Peregrin | protein | 110 | 64% helix, 0% strand | P55201 |
| B | Peregrin | protein | 111 | 62% helix, 0% strand | P55201 |
| C | Histone H4 | protein | 10 | 0% helix, 0% strand | Q0VAS5 |
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 102 | 0.56 | 0.85 | 25 | empty |
Interfaces
3 interfaces between chains.
- A–C · 535 Ų buried · 4 hydrogen bonds · protein-protein
- B–C · 338 Ų buried · 2 hydrogen bonds · protein-protein
- A–B · 262 Ų buried · 5 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 modified (acetylation).
Compared structures
- 5FFW · Crystal structure of the bromodomain of human BRPF1 in complex with H4K5acK8ac histone… · the same entry in another collection · chain A against A, TM-score 1.00
- P55201 · AlphaFold monomer V2.0 prediction for peregrin (P55201) · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P55201
- Every structure of UniProt Q0VAS5
- Elsewhere: RCSB PDB 5FFW · PDBe 5FFW · UniProt P55201 · UniProt Q0VAS5
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