Research workbench
Crystal structure of the bromodomain of human BRPF1 in complex with H4K5ACK8AC histone peptide
Analyse Crystal structure of the bromodomain of human BRPF1 in complex with H4K5ACK8AC… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5FFW
- Type
- protein
- Length
- 231 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Peregrin; Histone H4
- UniProt
- P55201, Q0VAS5
- Pockets
- 1 · best druggability 0.56
Structure
x-ray diffraction · 3 distinct chains · 60% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Peregrin | protein | 110 | 64% helix, 0% strand | P55201 |
| B | Peregrin | protein | 111 | 62% helix, 0% strand | P55201 |
| C | Histone H4 | protein | 10 | 0% helix, 0% strand | Q0VAS5 |
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 102 | 0.56 | 0.85 | 25 | empty |
Interfaces
3 interfaces between chains.
- A–C · 535 Ų buried · 4 hydrogen bonds · protein-protein
- B–C · 338 Ų buried · 2 hydrogen bonds · protein-protein
- A–B · 262 Ų buried · 5 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 modified (acetylation).
Compared structures
- 5FFW · Crystal structure of the bromodomain of human BRPF1 in complex with H4K5acK8ac histone… · the same entry in another collection · chain A against A, TM-score 1.00
- P55201 · AlphaFold monomer V2.0 prediction for peregrin (P55201) · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P55201
- Every structure of UniProt Q0VAS5
- Elsewhere: RCSB PDB 5FFW · PDBe 5FFW · UniProt P55201 · UniProt Q0VAS5
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.