UniProt P55201
Peregrin (P55201)
Peregrin (UniProt P55201): 105 experimental structures and 1 predicted model on GenesisL1, 40 ligands bound, 25 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P55201
- Protein
- Peregrin
- Experimental structures
- 105
- Predicted models
- 1
- Ligands
- 40
- Pockets
- 25 · 4 records with a druggable one
Structures
106 records of P55201 in the MolNFT archive: 105 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2RS9 | Solution structure of the bromodomain of human BRPF1 in complex with histone H4K5ac peptide | solution nmr | B | — | — |
| 2RS9 | Solution structure of the bromodomain of human BRPF1 in complex with histone H4K5AC peptide | solution nmr | B | — | — |
| 2X35 | Molecular basis of Histone H3K36me3 recognition by the PWWP domain of BRPF1. | x-ray diffraction | A | — | — |
| 2X35 | Molecular basis of histone H3K36ME3 recognition by the pwwp domain of BRPF1. | x-ray diffraction | A | — | — |
| 2X4W | Molecular basis of Histone H3K36me3 recognition by the PWWP domain of BRPF1. | x-ray diffraction | A | — | — |
| 2X4W | Molecular basis of histone H3K36ME3 recognition by the pwwp domain of BRPF1. | x-ray diffraction | A | — | — |
| 2X4X | Molecular basis of Histone H3K36me3 recognition by the PWWP domain of BRPF1. | x-ray diffraction | A, C, E, G | — | — |
| 2X4X | Molecular basis of histone H3K36ME3 recognition by the pwwp domain of BRPF1. | x-ray diffraction | A, C, E, G | — | — |
| 2X4Y | Molecular basis of Histone H3K36me3 recognition by the PWWP domain of BRPF1. | x-ray diffraction | A, C, E, G, I, K, M, O | — | — |
| 2X4Y | Molecular basis of histone H3K36ME3 recognition by the pwwp domain of BRPF1. | x-ray diffraction | A, C, E, G, I, K, M, O | — | — |
| 3L42 | PWWP domain of human bromodomain and PHD finger containing protein 1 | x-ray diffraction | A | — | — |
| 3L42 | Pwwp domain of human bromodomain and phd finger containing protein 1 | x-ray diffraction | A | — | — |
| 3MO8 | PWWP Domain of Human Bromodomain and PHD finger-containing protein 1 In Complex with Trimethylated… | x-ray diffraction | A | — | — |
| 3MO8 | Pwwp domain of human bromodomain and phd finger-containing protein 1 in complex with trimethylated… | x-ray diffraction | A | — | — |
| 4LC2 | Crystal structure of the bromodomain of human BRPF1B | x-ray diffraction | A | — | — |
| 4LC2 | Crystal structure of the bromodomain of human BRPF1B | x-ray diffraction | A | — | — |
| 4QYD | Crystal Structure of the human BRPF1 bromodomain in complex with a histone H4K12ac peptide | x-ray diffraction | A | — | — |
| 4QYD | Crystal structure of the human BRPF1 bromodomain in complex with a histone H4K12AC peptide | x-ray diffraction | A | — | — |
| 4QYL | Crystal Structure of the human BRPF1 bromodomain in complex with a histone H2AK5ac peptide | x-ray diffraction | A, B, C, D | — | — |
| 4QYL | Crystal structure of the human BRPF1 bromodomain in complex with a histone H2AK5AC peptide | x-ray diffraction | A, B, C, D | — | — |
| 4UYE | BROMODOMAIN OF HUMAN BRPF1 WITH N-1,3-dimethyl-2-oxo-6-(piperidin-1… | x-ray diffraction | A, B | — | — |
| 4UYE | Bromodomain of human BRPF1 with N-1,3-dimethyl-2-oxo-6-(… | x-ray diffraction | A, B | — | — |
| 5C6S | Human Bromodomain and PHD Finger Containing 1, PWWP domain in complex with XST005904a | x-ray diffraction | A | 4K8, CL, UNX | — |
| 5C6S | Human bromodomain and phd finger containing 1, pwwp domain in complex with XST005904A | x-ray diffraction | A | — | — |
| 5C7N | Crystal structure of the human BRPF1 bromodomain in complex with Bromosporine | x-ray diffraction | A | — | — |
| 5C7N | Crystal structure of the human BRPF1 bromodomain in complex with bromosporine | x-ray diffraction | A | — | — |
| 5C85 | Crystal structure of the human BRPF1 bromodomain in complex with SEED1 | x-ray diffraction | A | NO3, 4YO | 1 (best 0.48) |
| 5C85 | Crystal structure of the human BRPF1 bromodomain in complex with SEED1 | x-ray diffraction | A | — | — |
| 5C87 | Crystal structure of the human BRPF1 bromodomain in complex with SEED2 | x-ray diffraction | A | — | — |
| 5C89 | Crystal structure of the human BRPF1 bromodomain in complex with 917 | x-ray diffraction | A | — | — |
| 5C89 | Crystal structure of the human BRPF1 bromodomain in complex with 917 | x-ray diffraction | A | — | — |
| 5D7X | Crystal structure of the human BRPF1 bromodomain in complex with XZ08 | x-ray diffraction | A | NO3, XZ8 | 1 (best 0.48) |
| 5D7X | Crystal structure of the human BRPF1 bromodomain in complex with XZ08 | x-ray diffraction | A | — | — |
| 5DY7 | Crystal structure of the human BRPF1 bromodomain in complex with SEED4 | x-ray diffraction | A | 5GT, NO3 | 1 (best 0.47) |
| 5DY7 | Crystal structure of the human BRPF1 bromodomain in complex with SEED4 | x-ray diffraction | A | — | — |
| 5DYA | Crystal structure of the human BRPF1 bromodomain in complex with SEED5 | x-ray diffraction | A | NO3 | — |
| 5DYA | Crystal structure of the human BRPF1 bromodomain in complex with SEED5 | x-ray diffraction | A | — | — |
| 5DYC | Crystal structure of the human BRPF1 bromodomain in complex with SEED6 | x-ray diffraction | A | NO3 | — |
| 5DYC | Crystal structure of the human BRPF1 bromodomain in complex with SEED6 | x-ray diffraction | A | — | — |
| 5E3D | Crystal structure of the human BRPF1 bromodomain in complex with SEED7 | x-ray diffraction | A | — | — |
| 5E3G | Crystal structure of the human BRPF1 bromodomain in complex with SEED8 | x-ray diffraction | A | 5JQ, NO3 | — |
| 5E3G | Crystal structure of the human BRPF1 bromodomain in complex with SEED8 | x-ray diffraction | A | — | — |
| 5EM3 | Crystal structure of the human BRPF1 bromodomain in complex with SEED9 | x-ray diffraction | A | — | — |
| 5EPR | Crystal structure of the human BRPF1 bromodomain in complex with SEED11 | x-ray diffraction | A | 5QY, NO3 | 1 (best 0.49) |
| 5EPR | Crystal structure of the human BRPF1 bromodomain in complex with SEED11 | x-ray diffraction | A | — | — |
| 5EPS | Crystal structure of the human BRPF1 bromodomain in complex with SEED10 | x-ray diffraction | A | — | — |
| 5EQ1 | Crystal structure of the human BRPF1 bromodomain in complex with SEED12 | x-ray diffraction | A | BEA, NO3 | — |
| 5EQ1 | Crystal structure of the human BRPF1 bromodomain in complex with SEED12 | x-ray diffraction | A | — | — |
| 5ERC | X-ray crystal structure of BRPF1 PZP domain | x-ray diffraction | A | ZN, CA | — |
| 5ERC | X-ray crystal structure of BRPF1 pzp domain | x-ray diffraction | A | — | — |
| 5ETB | Crystal structure of the human BRPF1 bromodomain in complex with SEED13 | x-ray diffraction | A | 5RO, NO3 | 1 (best 0.48) |
| 5ETB | Crystal structure of the human BRPF1 bromodomain in complex with SEED13 | x-ray diffraction | A | — | — |
| 5ETD | Crystal structure of the human BRPF1 bromodomain in complex with SEED14 | x-ray diffraction | A | 5RN, NO3 | — |
| 5ETD | Crystal structure of the human BRPF1 bromodomain in complex with SEED14 | x-ray diffraction | A | — | — |
| 5EV9 | Crystal structure of the human BRPF1 bromodomain in complex with SEED15 | x-ray diffraction | A | — | — |
| 5EVA | Crystal structure of the human BRPF1 bromodomain in complex with SEED16 | x-ray diffraction | A | — | — |
| 5EWC | Crystal structure of the human BRPF1 bromodomain in complex with SEED17 | x-ray diffraction | A | — | — |
| 5EWD | Crystal structure of the human BRPF1 bromodomain in complex with SEED18 | x-ray diffraction | A | 5SH, NO3 | 1 (best 0.48) |
| 5EWD | Crystal structure of the human BRPF1 bromodomain in complex with SEED18 | x-ray diffraction | A | — | — |
| 5EWH | Crystal structure of the human BRPF1 bromodomain in complex with SEED19 | x-ray diffraction | A | 5SG, NO3 | — |
46 records more on the page itself.
Ligands
- NO3 · Nitrate ion · in 32 records
- B0H · ~{N}-[4-[[(3~{S},5~{R})-3,5-dimethylpiperidin-1-yl]methyl]-1,3-thiazol-2-yl]-2,4-dimethyl-1,3-oxazole-5-carboxamide · in 3 records
- 9KT · 1,4-dimethylquinoxaline-2,3-dione · in 2 records
- 9LK · ~{N}-[6-(4-chloranylphenoxy)pyridin-3-yl]-2,4-dimethyl-1,3-oxazole-5-carboxamide · in 2 records
- 9LT · 1-ethyl-~{N}-[(~{R})-(3-fluorophenyl)-(1-methylimidazol-2-yl)methyl]-2,3-bis(oxidanylidene)-4~{H}-quinoxaline-6-carboxamide · in 2 records
- LS8 · 4-cyano-~{N}-(1,3-dimethyl-2-oxidanylidene-quinolin-6-yl)-2-methoxy-benzenesulfonamide · in 2 records
- UWX · ~{N}-[1,4-dimethyl-7-morpholin-4-yl-2,3-bis(oxidanylidene)quinoxalin-6-yl]-4-(2-methylpropyl) benzenesulfonamide · in 2 records
- WGX · ~{N}-[1,4-dimethyl-2,3-bis(oxidanylidene)-7-piperidin-1-yl-quinoxalin-6-yl]-5,6,7,8-tetrahydronaphthalene-2-sulfonamide · in 2 records
- ZN · Zinc ion · in 2 records
- 12Q · 1-methylquinolin-2(1H)-one · in 1 record
- 4K8 · isoquinoline-3-carboxylic acid · in 1 record
- 4YO · 6-bromo-3,4-dihydroquinoxalin-2(1H)-one · in 1 record
- 5GT · 7-(trifluoromethyl)-3,4-dihydroquinoxalin-2(1H)-one · in 1 record
- 5JQ · 2-thioxo-2,3,7,9-tetrahydro-1H-purine-6,8-dione · in 1 record
- 5QY · (3~{S})-3-methyl-3,4-dihydro-1~{H}-quinoxalin-2-one · in 1 record
- 5RN · 1-(1~{H}-indol-3-yl)ethanone · in 1 record
- 5RO · 1-(7-methyl-1~{H}-indol-3-yl)ethanone · in 1 record
- 5SG · isoquinolin-5-ol · in 1 record
- 5SH · 4-phenylpyridine · in 1 record
- 5SN · 1,5-dimethyl-[1,2,4]triazolo[4,3-a]quinoline · in 1 record
- 5XD · 4-ethyl-~{N}-(6-methoxy-1,3-dimethyl-2-oxidanylidene-benzimidazol-5-yl)benzenesulfonamide · in 1 record
- 5XE · 4-bromanyl-~{N}-(6-methoxy-1,3-dimethyl-2-oxidanylidene-benzimidazol-5-yl)-2-methyl-benzenesulfonamide · in 1 record
- 5XF · ~{N}-(1,3-dimethyl-2-oxidanylidene-6-pyrrolidin-1-yl-benzimidazol-5-yl)-2-methoxy-benzamide · in 1 record
- 8VI · N-[1,3-dimethyl-6-[(2R)-2-methylpiperazin-1-yl]-2-oxidanylidene-benzimidazol-5-yl]-N-ethyl-2-methoxy-benzamide · in 1 record
- 9KW · ~{N}-[1,4-dimethyl-7-morpholin-4-yl-2,3-bis(oxidanylidene)quinoxalin-6-yl]-5,6,7,8-tetrahydronaphthalene-2-sulfonamide · in 1 record
- 9L5 · ~{N}-[(1~{S})-1-(1,5-dimethylpyrazol-4-yl)ethyl]-1-ethyl-3-methyl-2-oxidanylidene-quinoxaline-6-carboxamide · in 1 record
- 9LN · 1-ethyl-~{N}-methyl-2,3-bis(oxidanylidene)-~{N}-[(1-phenylpyrazol-4-yl)methyl]-4~{H}-quinoxaline-6-carboxamide · in 1 record
- AXN · ~{N}-[1,4-dimethyl-2,3-bis(oxidanylidene)-7-pyrrolidin-1-yl-quinoxalin-6-yl]-4-(2-methylpropyl) benzenesulfonamide · in 1 record
- AYW · 4-methyl-6-oxidanyl-1-benzofuran-3-one · in 1 record
- B0E · 1,3-bis(oxidanyl)benzo[c]chromen-6-one · in 1 record
Experiment against prediction
- 5ERC chain A against the predicted model P55201: TM-score 0.99, RMSD 0.47 Å
- 5ERC chain A against the predicted model P55201: TM-score 0.99, RMSD 0.47 Å
- 2X4X chain G against the predicted model P55201: TM-score 0.99, RMSD 0.47 Å
- 2X4X chain G against the predicted model P55201: TM-score 0.99, RMSD 0.47 Å
- 2X4Y chain G against the predicted model P55201: TM-score 0.99, RMSD 0.52 Å
- 2X4Y chain G against the predicted model P55201: TM-score 0.99, RMSD 0.52 Å
- 2X4X chain C against the predicted model P55201: TM-score 0.98, RMSD 0.52 Å
- 2X4X chain C against the predicted model P55201: TM-score 0.98, RMSD 0.52 Å
- 2X4Y chain C against the predicted model P55201: TM-score 0.98, RMSD 0.55 Å
- 2X4Y chain C against the predicted model P55201: TM-score 0.98, RMSD 0.55 Å
Elsewhere
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