MolNFT v1 · #118715 · protein

N184K pathological variant of gelsolin domain 2 (orthorhombic form)

5FAF: “N184K pathological variant of gelsolin domain 2 (orthorhombic form)”. X-ray diffraction, 2 ligands (CA, CL). MolNFT v1 #118715 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 5FAF
Type: protein
Length: 113 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Gelsolin
UniProt: P06396
Ligands: CA, CL

Structure

x-ray diffraction · 1 distinct chain · 25% helix, 25% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Gelsolin	protein	113	25% helix, 25% strand	P06396

Ligands and binding sites

CA · Calcium ion · metal · 2 copies · chains A
CL · Chloride ion · ion · 2 copies · chains A
GOL · Glycerol · additive · 3 copies · chains A
ACT · Acetate ion · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Modifications

Observed in the structure: 1 disulfide (disulfide).

Compared structures

5FAF · N184K pathological variant of gelsolin domain 2 (orthorhombic form) · the same entry in another collection · chain A against A, TM-score 1.00
P06396 · AlphaFold monomer V2.0 prediction for gelsolin (P06396) · a predicted model of the same protein · chain A against A, TM-score 0.86

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P06396
Elsewhere: RCSB PDB 5FAF · PDBe 5FAF · UniProt P06396

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