MolNFT v1 · #118417 · protein
Structural basis of ebola virus entry: viral glycoprotein bound to its endosomal receptor niemann-pick C1
5F18 · Niemann-pick C1 protein: “Structural basis of ebola virus entry: viral glycoprotein bound to its endosomal receptor niemann-pick C1”. X-ray diffraction, 2 pockets (best druggability 0.55). MolNFT v1 #118417 on GenesisL1: 3D…
- PDB
- 5F18
- Type
- protein
- Length
- 221 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Niemann-pick C1 protein
- UniProt
- O15118
- Pockets
- 2 · best druggability 0.55
Structure
x-ray diffraction · 1 distinct chain · 36% helix, 21% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Niemann-pick C1 protein | protein | 221 | 36% helix, 21% strand | O15118 |
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 134 | 0.55 | 0.82 | 28 | empty |
| 2 | 54 | 0.26 | 0.73 | 22 | empty |
Modifications
Observed in the structure: 2 disulfide (disulfide).
Compared structures
- 5F18 · Structural basis of Ebola virus entry: viral glycoprotein bound to its endosomal receptor… · the same entry in another collection · chain A against A, TM-score 1.00
- O15118 · AlphaFold monomer V2.0 prediction for npc intracellular cholesterol transporter 1 (O15118) · a predicted model of the same protein · chain A against A, TM-score 0.88
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O15118
- Elsewhere: RCSB PDB 5F18 · PDBe 5F18 · UniProt O15118
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