AlphaFold monomer V2.0 prediction for npc intracellular cholesterol transporter 1 (O15118)

Structure

1 distinct chain · 53% helix, 11% strand (DSSP).

Pockets

14 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.

Modifications

Observed in the structure: 15 disulfide (disulfide).

Compared structures

• 6W5U · NPC1 structure in gdn micelles at pH 5.5, conformation B · an experimental structure of the same protein · chain A against A, TM-score 0.88
• 6W5R · NPC1 structure in nanodisc · an experimental structure of the same protein · chain A against A, TM-score 0.84
• 6W5S · NPC1 structure in gdn micelles at pH 8.0 · an experimental structure of the same protein · chain A against A, TM-score 0.83
• 6W5T · NPC1 structure in gdn micelles at pH 5.5, conformation a · an experimental structure of the same protein · chain A against A, TM-score 0.83
• 6W5V · NPC1-NPC2 complex structure at pH 5.5 · an experimental structure of the same protein · chain A against A, TM-score 0.83
• 6UOX · Structure of itraconazole-bound NPC1 · an experimental structure of the same protein · chain A against A, TM-score 0.80
• 3JD8 · Cryo-EM structure of the full-length human NPC1 at 4.4 ångström · an experimental structure of the same protein · chain A against A, TM-score 0.76
• 3JD8 · cryo-EM structure of the full-length human NPC1 at 4.4 angstrom · an experimental structure of the same protein · chain A against A, TM-score 0.76
• 5JNX · The 6.6 A cryo-EM structure of the full-length human NPC1 in complex with the cleaved… · an experimental structure of the same protein · chain A against A, TM-score 0.76
• 5JNX · The 6.6 a cryo-EM structure of the full-length human NPC1 in complex with the cleaved… · an experimental structure of the same protein · chain A against A, TM-score 0.76
• 5U73 · Crystal structure of human niemann-pick C1 protein · an experimental structure of the same protein · chain A against A, TM-score 0.68
• 5U74 · Structure of human niemann-pick C1 protein · an experimental structure of the same protein · chain A against A, TM-score 0.67

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt O15118
• Elsewhere: UniProt O15118 · AlphaFold DB O15118