UniProt O15118
NPC intracellular cholesterol transporter 1 (O15118)
NPC intracellular cholesterol transporter 1 (UniProt O15118): 33 experimental structures and 1 predicted model on GenesisL1, 7 ligands bound, 106 pockets. Binding sites, druggability and experiment against prediction (TM-score)…
- UniProt
- O15118
- Protein
- NPC intracellular cholesterol transporter 1
- Experimental structures
- 33
- Predicted models
- 1
- Ligands
- 7
- Pockets
- 106 · 9 records with a druggable one
Structures
34 records of O15118 in the MolNFT archive: 33 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3GKH | NPC1(NTD) | x-ray diffraction | A | — | — |
| 3GKH | NPC1(NTD) | x-ray diffraction | A | — | — |
| 3GKI | NPC1(NTD):cholesterol | x-ray diffraction | A | — | — |
| 3GKI | NPC1(NTD):CHOLESTEROL | x-ray diffraction | A | — | — |
| 3GKJ | NPC1D(NTD):25hydroxycholesterol | x-ray diffraction | A | — | — |
| 3GKJ | NPC1D(NTD):25HYDROXYCHOLESTEROL | x-ray diffraction | A | — | — |
| 3JD8 | cryo-EM structure of the full-length human NPC1 at 4.4 angstrom | electron microscopy | A | — | — |
| 3JD8 | Cryo-EM structure of the full-length human NPC1 at 4.4 ångström | electron microscopy | A | — | — |
| 5F18 | Structural basis of Ebola virus entry: viral glycoprotein bound to its endosomal receptor… | x-ray diffraction | A | — | 2 (best 0.55) |
| 5F18 | Structural basis of ebola virus entry: viral glycoprotein bound to its endosomal receptor… | x-ray diffraction | A | — | — |
| 5F1B | Structural basis of Ebola virus entry: viral glycoprotein bound to its endosomal receptor… | x-ray diffraction | C | — | — |
| 5F1B | Structural basis of ebola virus entry: viral glycoprotein bound to its endosomal receptor… | x-ray diffraction | C | — | — |
| 5HNS | Structure of glycosylated NPC1 luminal domain C | x-ray diffraction | A, B | NAG, BMA, SCN | — |
| 5HNS | Structure of glycosylated NPC1 luminal domain C | x-ray diffraction | A, B | — | — |
| 5JNX | The 6.6 A cryo-EM structure of the full-length human NPC1 in complex with the cleaved glycoprotein… | electron microscopy | A | NAG, BMA | — |
| 5JNX | The 6.6 a cryo-EM structure of the full-length human NPC1 in complex with the cleaved glycoprotein… | electron microscopy | A | — | — |
| 5KWY | Structure of human NPC1 middle lumenal domain bound to NPC2 | x-ray diffraction | A, B | — | — |
| 5KWY | Structure of human NPC1 middle lumenal domain bound to NPC2 | x-ray diffraction | A, B | — | — |
| 5U73 | Crystal structure of human Niemann-Pick C1 protein | x-ray diffraction | A | NAG, MAN | 8 (best 0.88) |
| 5U73 | Crystal structure of human niemann-pick C1 protein | x-ray diffraction | A | NAG, MAN | — |
| 5U74 | Structure of human Niemann-Pick C1 protein | x-ray diffraction | A | NAG, MAN | 9 (best 0.88) |
| 5U74 | Structure of human niemann-pick C1 protein | x-ray diffraction | A | NAG, MAN | — |
| 6UOX | Structure of itraconazole-bound NPC1 | electron microscopy | A | NAG, MAN, QDG | — |
| 6W5R | NPC1 structure in Nanodisc | electron microscopy | A | NAG, BMA, CLR | 15 (best 0.87) |
| 6W5R | NPC1 structure in nanodisc | electron microscopy | A | NAG, BMA, CLR | — |
| 6W5S | NPC1 structure in GDN micelles at pH 8.0 | electron microscopy | A | NAG, MAN, CLR, POV | 16 (best 0.87) |
| 6W5S | NPC1 structure in gdn micelles at pH 8.0 | electron microscopy | A | NAG, MAN, CLR, POV | — |
| 6W5T | NPC1 structure in gdn micelles at pH 5.5, conformation a | electron microscopy | A | NAG, MAN, CLR | — |
| 6W5U | NPC1 structure in GDN micelles at pH 5.5, conformation b | electron microscopy | A | NAG, BMA, CLR | 19 (best 0.86) |
| 6W5U | NPC1 structure in gdn micelles at pH 5.5, conformation B | electron microscopy | A | NAG, BMA, CLR | — |
| 6W5V | NPC1-NPC2 complex structure at pH 5.5 | electron microscopy | A | NAG, BMA, CLR | 18 (best 0.89) |
| 6W5V | NPC1-NPC2 complex structure at pH 5.5 | electron microscopy | A | NAG, BMA, CLR | — |
| 8EUS | Crystal structure of NPC1 luminal domain C | x-ray diffraction | C, A | — | 5 (best 0.69) |
| O15118 | AlphaFold monomer V2.0 prediction for npc intracellular cholesterol transporter 1 (O15118) | predicted | A | — | 14 (best 0.84) |
Ligands
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 16 records
- CLR · Cholesterol · in 9 records
- BMA · beta-D-mannopyranose · in 8 records
- MAN · alpha-D-mannopyranose · in 8 records
- POV · (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate · in 2 records
- QDG · 4-(3-bromo-4-{4-[4-({(2R,4S)-2-(2,4-dichlorophenyl)-2-[(1H-1,2,4-triazol-1-yl)methyl]-1,3-dioxolan-4-yl}methoxy)phenyl]piperazin-1-yl}phenyl)-2-[(2S)-butan-2-yl]-2,4-dihydro-3H-1,2,4-triazol-3-one · in 1 record
- SCN · Thiocyanate ion · in 1 record
Experiment against prediction
- 8EUS chain C against the predicted model O15118: TM-score 0.99, RMSD 0.60 Å
- 3GKH chain A against the predicted model O15118: TM-score 0.98, RMSD 0.80 Å
- 3GKH chain A against the predicted model O15118: TM-score 0.98, RMSD 0.80 Å
- 3GKI chain A against the predicted model O15118: TM-score 0.98, RMSD 0.80 Å
- 3GKI chain A against the predicted model O15118: TM-score 0.98, RMSD 0.80 Å
- 3GKJ chain A against the predicted model O15118: TM-score 0.98, RMSD 0.85 Å
- 3GKJ chain A against the predicted model O15118: TM-score 0.98, RMSD 0.85 Å
- 8EUS chain A against the predicted model O15118: TM-score 0.98, RMSD 0.75 Å
- 5KWY chain A against the predicted model O15118: TM-score 0.98, RMSD 0.96 Å
- 5KWY chain A against the predicted model O15118: TM-score 0.98, RMSD 0.96 Å
Elsewhere
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