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Ligand · HC3

HC3 · 25-hydroxycholesterol

HC3, 25-hydroxycholesterol (C27 H46 O2, 402.7 g/mol), in the MolNFT structures on GenesisL1: bound in 11 records (7 PDB entries). Every binding site with its residues within 4.5 Å, the residues it binds most and the ligands found with it.

Component
HC3
Formula
C27 H46 O2
Class
ligand
Structures
11
PDB entries
7

Binding sites

HC3 in 11 structures; the first of them:

  • 6BYM · Crystal structure of the sterol-bound second StART domain of yeast Lam4 · HC3 A301 · binds TYR87, LYS89, LEU91, ILE95, GLY96, PRO97, THR100, CYS102 and 16 more
  • 6GQF · The structure of mouse AsterA (GramD1a) with 25-hydroxy cholesterol · HC3 A601 · binds TYR427, ILE429, ASN433, LEU435, VAL464, THR466, PRO470, PHE475 and 6 more
  • 6T4X · ROR(gamma)t ligand binding domain in complex with 25-hydroxycholesterol and allosteric… · HC3 A601 · binds CYS285, GLN286, LEU287, CYS320, HIS323, LEU324, ALA327, VAL361 and 16 more
  • 6T50 · ROR(gamma)t ligand binding domain in complex with 25-hydroxycholesterol and allosteric… · HC3 A601 · binds GLN286, CYS320, HIS323, LEU324, ALA327, VAL361, ARG364, MET365 and 8 more
  • 8IVF · FABP7 complexed with 25-HC · HC3 B1001 · binds PHE17, TYR20, MET21, LEU24, VAL26, THR30, VAL33, GLY34 and 14 more
  • 6BYM · Crystal structure of the sterol-bound second start domain of yeast LAM4 · HC3 A301 · binds TYR87, LYS89, ILE95, GLY96, CYS102, GLN121, THR123, THR125 and 8 more
  • 6GQF · The structure of mouse astera (GRAMD1A) with 25-hydroxy cholesterol · HC3 A601 · binds TYR427, ILE429, ASN433, LEU435, VAL464, THR466, PRO470, PHE475 and 6 more
  • 6M49 · Cryo-EM structure of SCAP/INSIG complex in the present of 25-hydroxyl cholesterol. · HC3 A501 · binds VAL114, GLY117, HIS120, ALA121, GLY143, LEU144, LEU343, TYR351 and 2 more
  • 6T4X · ROR(GAMMA)T ligand binding domain in complex with 25- hydroxycholesterol and allosteric… · HC3 A601 · binds GLN286, CYS320, HIS323, LEU324, VAL361, ARG364, MET365, PHE378 and 6 more
  • 6T4Y · ROR(GAMMA)T ligand binding domain in complex with 25- hydroxycholesterol and allosteric… · HC3 A601 · binds GLN286, LEU287, CYS320, HIS323, LEU324, VAL361, ARG364, MET365 and 6 more
  • 6T50 · ROR(GAMMA)T ligand binding domain in complex with 25- hydroxycholesterol and allosteric… · HC3 A601 · binds GLN286, CYS320, HIS323, LEU324, ALA327, VAL361, ARG364, MET365 and 8 more

Residues it binds most

LEU 14, PHE 19, ILE 14, VAL 18, THR 14, TYR 15, HIS 14, SER 13, GLY 11, PRO 14 (residue and the binding sites it lines).

Found with

  • GOL · Glycerol
  • L3E · 4-[(~{E})-[3-[2-chloranyl-6-(trifluoromethyl)phenyl]-5-(1~{H}-pyrrol-3-yl)-1,2-oxazol-4-yl]methylideneamino]benzoic acid
  • MJE · 4-[1-[2,6-bis(chloranyl)phenyl]carbonyl-5-methyl-thieno[3,2-c]pyrazol-3-yl]benzoic acid
  • 4F1 · 4-{1-[2-chloro-6-(trifluoromethyl)benzoyl]-1H-indazol-3-yl}benzoic acid

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