Research workbench
AlphaFold monomer V2.0 prediction for npc intracellular cholesterol transporter 1 (O15118)
Analyse AlphaFold monomer V2.0 prediction for npc intracellular cholesterol transporter… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- Accession
- O15118
- Type
- protein
- Length
- 1,278 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0x22b7Fb1e0672534F7F94F5B4B1755D26b481FfA6
- Molecule
- Npc intracellular cholesterol transporter 1
- UniProt
- O15118
- Pockets
- 14 · best druggability 0.84
Structure
1 distinct chain · 53% helix, 11% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Npc intracellular cholesterol transporter 1 | protein | 1278 | 53% helix, 11% strand | O15118 |
Pockets
14 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 342 | 0.84 | 0.93 | 51 | empty |
| 2 | 249 | 0.81 | 0.93 | 43 | empty |
| 3 | 215 | 0.78 | 0.92 | 45 | empty |
| 4 | 635 | 0.74 | 0.80 | 52 | empty |
| 5 | 415 | 0.73 | 0.83 | 40 | empty |
Modifications
Observed in the structure: 15 disulfide (disulfide).
Compared structures
- 6W5U · NPC1 structure in gdn micelles at pH 5.5, conformation B · an experimental structure of the same protein · chain A against A, TM-score 0.88
- 6W5U · NPC1 structure in GDN micelles at pH 5.5, conformation b · an experimental structure of the same protein · chain A against A, TM-score 0.88
- 6W5R · NPC1 structure in nanodisc · an experimental structure of the same protein · chain A against A, TM-score 0.84
- 6W5R · NPC1 structure in Nanodisc · an experimental structure of the same protein · chain A against A, TM-score 0.84
- 6W5S · NPC1 structure in gdn micelles at pH 8.0 · an experimental structure of the same protein · chain A against A, TM-score 0.83
- 6W5S · NPC1 structure in GDN micelles at pH 8.0 · an experimental structure of the same protein · chain A against A, TM-score 0.83
- 6W5T · NPC1 structure in gdn micelles at pH 5.5, conformation a · an experimental structure of the same protein · chain A against A, TM-score 0.83
- 6W5T · NPC1 structure in GDN micelles at pH 5.5, conformation a · an experimental structure of the same protein · chain A against A, TM-score 0.83
- 6W5V · NPC1-NPC2 complex structure at pH 5.5 · an experimental structure of the same protein · chain A against A, TM-score 0.83
- 6W5V · NPC1-NPC2 complex structure at pH 5.5 · an experimental structure of the same protein · chain A against A, TM-score 0.83
- 6UOX · Structure of itraconazole-bound NPC1 · an experimental structure of the same protein · chain A against A, TM-score 0.80
- 6UOX · Structure of itraconazole-bound NPC1 · an experimental structure of the same protein · chain A against A, TM-score 0.80
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O15118
- Elsewhere: UniProt O15118 · AlphaFold DB O15118
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