MolNFT v1 · #117982 · protein
Crystal structure of optn ntd and TBK1 ctd complex
5EOF · Optineurin: “Crystal structure of optn ntd and TBK1 ctd complex”. X-ray diffraction. MolNFT v1 #117982 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5EOF
- Type
- protein
- Length
- 232 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Optineurin; SERINE/THREONINE-protein kinase TBK1
- EC
- 2.7.11.1
- UniProt
- Q96CV9, Q9UHD2
Structure
x-ray diffraction · 3 distinct chains · 86% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Optineurin | protein | 74 | 84% helix, 0% strand | Q96CV9 |
| C | SERINE/THREONINE-protein kinase TBK1 (EC 2.7.11.1) | protein | 43 | 81% helix, 0% strand | Q9UHD2 |
| D | SERINE/THREONINE-protein kinase TBK1 (EC 2.7.11.1) | protein | 41 | 95% helix, 0% strand | Q9UHD2 |
Interfaces
6 interfaces between chains.
- B–C · 1117 Ų buried · 7 hydrogen bonds · protein-protein
- B–D · 1043 Ų buried · 8 hydrogen bonds · protein-protein
- A–B · 991 Ų buried · 5 hydrogen bonds · protein-protein
- A–C · 987 Ų buried · 6 hydrogen bonds · protein-protein
- A–D · 977 Ų buried · 7 hydrogen bonds · protein-protein
Compared structures
- 5EOF · Crystal structure of OPTN NTD and TBK1 CTD complex · the same entry in another collection · chain A against A, TM-score 1.00
- Q96CV9 · AlphaFold monomer V2.0 prediction for optineurin (Q96CV9) · a predicted model of the same protein · chain A against A, TM-score 0.83
- Q9UHD2 · AlphaFold monomer V2.0 prediction for SERINE/THREONINE-protein kinase TBK1 (Q9UHD2) · a predicted model of the same protein · chain D against A, TM-score 0.83
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q96CV9
- Every structure of UniProt Q9UHD2
- Elsewhere: RCSB PDB 5EOF · PDBe 5EOF · UniProt Q96CV9 · UniProt Q9UHD2
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