UniProt Q9UHD2
Serine/threonine-protein kinase TBK1 (Q9UHD2)
Serine/threonine-protein kinase TBK1 (UniProt Q9UHD2), EC 2.7.11.1: 43 experimental structures on GenesisL1, 11 ligands bound, 20 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- Q9UHD2
- Protein
- Serine/threonine-protein kinase TBK1
- EC
- 2.7.11.1
- Experimental structures
- 43
- Predicted models
- 0
- Ligands
- 11
- Pockets
- 20 · 3 records with a druggable one
Structures
43 records of Q9UHD2 in the MolNFT archive: 43 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4EFO | Crystal structure of the ubiquitin-like domain of human TBK1 | x-ray diffraction | A, B | — | — |
| 4EFO | Crystal structure of the ubiquitin-like domain of human TBK1 | x-ray diffraction | A, B | — | — |
| 4EUT | Structure of BX-795 Complexed with Unphosphorylated Human TBK1 Kinase-ULD Domain | x-ray diffraction | A, B | — | — |
| 4EUT | Structure of bx-795 complexed with unphosphorylated human TBK1 kinase- uld domain | x-ray diffraction | A, B | — | — |
| 4EUU | Structure of BX-795 Complexed with Human TBK1 Kinase Domain Phosphorylated on Ser172 | x-ray diffraction | A, B | — | — |
| 4EUU | Structure of bx-795 complexed with human TBK1 kinase domain phosphorylated on SER172 | x-ray diffraction | A, B | — | — |
| 4IM0 | Structure of Tank-Binding Kinase 1 | x-ray diffraction | A | — | — |
| 4IM0 | Structure of tank-binding kinase 1 | x-ray diffraction | A | — | — |
| 4IM2 | Structure of Tank-Binding Kinase 1 | x-ray diffraction | A | — | — |
| 4IM2 | Structure of tank-binding kinase 1 | x-ray diffraction | A | — | — |
| 4IM3 | Structure of Tank-Binding Kinase 1 | x-ray diffraction | A | — | — |
| 4IM3 | Structure of tank-binding kinase 1 | x-ray diffraction | A | — | — |
| 4IW0 | Crystal structure and mechanism of activation of TBK1 | x-ray diffraction | A | — | — |
| 4IW0 | Crystal structure and mechanism of activation of TBK1 | x-ray diffraction | A | — | — |
| 4IWO | Crystal structure and mechanism of activation of TBK1 | x-ray diffraction | A | — | — |
| 4IWO | Crystal structure and mechanism of activation of TBK1 | x-ray diffraction | A | — | — |
| 4IWP | Crystal structure and mechanism of activation of TBK1 | x-ray diffraction | A | — | — |
| 4IWP | Crystal structure and mechanism of activation of TBK1 | x-ray diffraction | A | — | — |
| 4IWQ | Crystal structure and mechanism of activation of TBK1 | x-ray diffraction | A | — | — |
| 4IWQ | Crystal structure and mechanism of activation of TBK1 | x-ray diffraction | A | — | — |
| 5EOA | Crystal structure of OPTN E50K mutant and TBK1 complex | x-ray diffraction | C, D | — | — |
| 5EOA | Crystal structure of optn E50K mutant and TBK1 complex | x-ray diffraction | C, D | — | — |
| 5EOF | Crystal structure of OPTN NTD and TBK1 CTD complex | x-ray diffraction | C, D | — | — |
| 5EOF | Crystal structure of optn ntd and TBK1 ctd complex | x-ray diffraction | C, D | — | — |
| 5EP6 | The crystal structure of NAP1 in complex with TBK1 | x-ray diffraction | B, D | — | — |
| 5EP6 | The crystal structure of NAP1 in complex with TBK1 | x-ray diffraction | B, D | — | — |
| 5W5V | TBK1 co-crystal structure with amlexanox | x-ray diffraction | A | ANW | — |
| 6BNY | TBK1 in complex with tetrazole analog of amlexanox | x-ray diffraction | A | E0M | 8 (best 0.71) |
| 6BNY | TBK1 in complex with tetrazole analog of amlexanox | x-ray diffraction | A | E0M | — |
| 6BOD | TBK1 in complex with ethyl ester analog of amlexanox | x-ray diffraction | A | E0P | — |
| 6BOE | TBK1 in complex with amide-coupled tetrazole analog of amlexanox | x-ray diffraction | A | E0S | 6 (best 0.70) |
| 6BOE | TBK1 in complex with amide-coupled tetrazole analog of amlexanox | x-ray diffraction | A | E0S | — |
| 6CQ0 | TBK1 in complex with dimethyl amino analog of amlexanox | x-ray diffraction | A | F8M | — |
| 6CQ4 | TBK1 in complex with cyclohexyl analog of amlexanox | x-ray diffraction | A | F8P | — |
| 6CQ5 | TBK1 in complex with sulfone analog of amlexanox | x-ray diffraction | A | F8S | — |
| 6NT9 | Cryo-EM structure of the complex between human TBK1 and chicken STING | electron microscopy | A, B | — | — |
| 6NT9 | Cryo-EM structure of the complex between human TBK1 and chicken sting | electron microscopy | A, B | — | — |
| 6O8B | Crystal structure of sting ctd in complex with TBK1 | x-ray diffraction | A, B | BX7 | — |
| 6RSR | TBK1 in complex with compound 2 | x-ray diffraction | A | KHT | — |
| 6RST | TBK1 in complex with inhibitor compound 24 | x-ray diffraction | A | KHQ | 6 (best 0.72) |
| 6RST | TBK1 in complex with inhibitor compound 24 | x-ray diffraction | A | KHQ | — |
| 6RSU | TBK1 in complex with inhibitor compound 35 | x-ray diffraction | A | KJB | — |
| Q9UHD2 | AlphaFold monomer V2.0 prediction for SERINE/THREONINE-protein kinase TBK1 (Q9UHD2) | — | — | — |
Ligands
- E0M · 2-amino-7-(propan-2-yl)-3-(1H-tetrazol-5-yl)-5H-[1]benzopyrano[2,3-b]pyridin-5-one · in 2 records
- E0S · 2-amino-5-oxo-7-(propan-2-yl)-N-(1H-tetrazol-5-yl)-5H-[1]benzopyrano[2,3-b]pyridine-3-carboxamide · in 2 records
- KHQ · 1-[4-[(1~{R})-1-[2-[[5-[1-(cyclopropylmethyl)pyrazol-4-yl]-1~{H}-benzimidazol-2-yl]amino]pyridin-4-yl]ethyl]piperazin-1-yl]-3,3,3-tris(fluoranyl)propan-1-one · in 2 records
- ANW · 2-amino-7-(1-methylethyl)-5-oxo-5H-chromeno[2,3-b]pyridine-3-carboxylic acid · in 1 record
- BX7 · N-(3-{[5-iodo-4-({3-[(thiophen-2-ylcarbonyl) amino]propyl}amino)pyrimidin-2-yl]amino}phenyl) pyrrolidine-1-carboxamide · in 1 record
- E0P · Ethyl 2-amino-5-oxo-7-(propan-2-yl)-5H-[1]benzopyrano[2,3-b]pyridine-3-carboxylate · in 1 record
- F8M · 2-amino-7-[3-(dimethylamino)propyl]-5-oxo-5H-[1]benzopyrano[2,3-b]pyridine-3-carboxylic acid · in 1 record
- F8P · 2-amino-7-(4,4-difluorocyclohexyl)-5-oxo-5H-[1]benzopyrano[2,3-b]pyridine-3-carboxylic acid · in 1 record
- F8S · 2-amino-7-(1,1-dioxo-1lambda~6~-thian-4-yl)-5-oxo-5H-[1]benzopyrano[2,3-b]pyridine-3-carboxylic acid · in 1 record
- KHT · ~{N}-(cyclopropen-1-ylmethyl)-2-[[4-[[4-[3,3,3-tris(fluoranyl)propanoyl]piperazin-1-yl]methyl]pyridin-2-yl]amino]-1~{H}-benzimidazole-5-carboxamide · in 1 record
- KJB · 3,3,3-tris(fluoranyl)-1-[4-[(1~{R})-1-[2-[[(2~{S})-5-(5-propan-2-yloxypyrimidin-4-yl)-2,3-dihydro-1~{H}-benzimidazol-2-yl]amino]pyridin-4-yl]ethyl]piperazin-1-yl]propan-1-one · in 1 record
Elsewhere
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