MolNFT v1 · #117823 · protein
Structure of dictyostelium discoideum myosin VII MYTH4-ferm MF1 domain, mutant 2
5EJQ · Myosin-I heavy chain: “Structure of dictyostelium discoideum myosin VII MYTH4-ferm MF1 domain, mutant 2”. X-ray diffraction, 3 ligands (GLY, SER, GLU), 6 pockets (best druggability 0.63). MolNFT v1 #117823 on GenesisL1: 3D…
- PDB
- 5EJQ
- Type
- protein
- Length
- 498 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Myosin-I heavy chain
- UniProt
- Q9U1M8
- Ligands
- GLY, SER, GLU
- Pockets
- 6 · best druggability 0.63
Structure
x-ray diffraction · 1 distinct chain · 51% helix, 13% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Myosin-I heavy chain | protein | 498 | 51% helix, 13% strand | Q9U1M8 |
Ligands and binding sites
- GLY · Glycine · ligand · chains A
- SER · Serine · ligand · chains A
- GLU · Glutamic acid · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
6 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 317 | 0.63 | 0.80 | 38 | empty |
| 2 | 87 | 0.48 | 0.82 | 23 | empty |
| 3 | 61 | 0.39 | 0.80 | 15 | empty |
| 4 | 70 | 0.31 | 0.74 | 15 | GLY |
| 5 | 64 | 0.31 | 0.74 | 13 | empty |
Compared structures
- 5EJQ · Structure of Dictyostelium Discoideum Myosin VII MyTH4-FERM MF1 domain, mutant 2 · the same entry in another collection · chain A against A, TM-score 1.00
- Q9U1M8 · AlphaFold monomer V2.0 prediction for myosin-I heavy chain (Q9U1M8) · a predicted model of the same protein · chain A against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9U1M8
- Elsewhere: RCSB PDB 5EJQ · PDBe 5EJQ · UniProt Q9U1M8
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