MolNFT v1 · #117763 · protein

Structure of rcl-cleaved vaspin (SERPINA12)

5EI0 · Serpin A12: “Structure of rcl-cleaved vaspin (SERPINA12)”. X-ray diffraction, 8 pockets (best druggability 0.73). MolNFT v1 #117763 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 5EI0
Type: protein
Length: 743 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Serpin A12
UniProt: Q8IW75
Pockets: 8 · best druggability 0.73

Structure

x-ray diffraction · 2 distinct chains · 30% helix, 38% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Serpin A12	protein	372	29% helix, 37% strand	Q8IW75
E	Serpin A12	protein	371	31% helix, 38% strand	Q8IW75

Pockets

8 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	949	0.73	0.77	90	empty
2	67	0.41	0.80	12	empty
3	113	0.40	0.75	21	empty
4	76	0.38	0.77	14	empty
5	104	0.38	0.75	17	empty

Interfaces

1 interface between chains.

A–E · 656 Å² buried · 9 hydrogen bonds · protein-protein

Compared structures

5EI0 · Structure of RCL-cleaved vaspin (serpinA12) · the same entry in another collection · chain A against A, TM-score 1.00
Q8IW75 · AlphaFold monomer V2.0 prediction for serpin A12 (Q8IW75) · a predicted model of the same protein · chain A against A, TM-score 0.90

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8IW75
Elsewhere: RCSB PDB 5EI0 · PDBe 5EI0 · UniProt Q8IW75

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