MolNFT v1 · #117216 · protein
Structure of voltage-gated two-pore channel TPC1 from arabidopsis thaliana
5E1J · Two pore calcium channel protein 1: “Structure of voltage-gated two-pore channel TPC1 from arabidopsis thaliana”. X-ray diffraction, 2 ligands (BA, CA), 11 pockets (best druggability 0.70). MolNFT v1 #117216 on GenesisL1: 3D…
- PDB
- 5E1J
- Type
- protein
- Length
- 616 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Two pore calcium channel protein 1
- UniProt
- Q94KI8
- Ligands
- BA, CA
- Pockets
- 11 · best druggability 0.70
Structure
x-ray diffraction · 1 distinct chain · 74% helix, 1% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Two pore calcium channel protein 1 | protein | 616 | 74% helix, 1% strand | Q94KI8 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
11 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 704 | 0.70 | 0.77 | 57 | empty |
| 2 | 115 | 0.69 | 0.91 | 28 | empty |
| 3 | 212 | 0.60 | 0.80 | 34 | empty |
| 4 | 100 | 0.44 | 0.79 | 22 | empty |
| 5 | 118 | 0.41 | 0.75 | 19 | empty |
Compared structures
- 5E1J · Structure of voltage-gated two-pore channel TPC1 from Arabidopsis thaliana · the same entry in another collection · chain A against A, TM-score 1.00
- Q94KI8 · AlphaFold monomer V2.0 prediction for two pore calcium channel protein 1 (Q94KI8) · a predicted model of the same protein · chain A against A, TM-score 0.93
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q94KI8
- Elsewhere: RCSB PDB 5E1J · PDBe 5E1J · UniProt Q94KI8
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