MolNFT v1 · #117189 · protein
Crystal structure of the active form of the proteolytic complex CLPP1 and CLPP2
5E0S · ATP-dependent clp protease proteolytic subunit 2: “Crystal structure of the active form of the proteolytic complex CLPP1 and CLPP2”. X-ray diffraction, 20 pockets (best druggability 0.75). MolNFT v1 #117189 on GenesisL1: 3D…
- PDB
- 5E0S
- Type
- protein
- Length
- 5,291 residues
- Chains
- 28
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- ATP-dependent clp protease proteolytic subunit 2; ATP-dependent clp protease proteolytic…
- EC
- 3.4.21.92
- UniProt
- P9WPC2, P9WPC4
- Pockets
- 20 · best druggability 0.75
Structure
x-ray diffraction · 10 distinct chains · 45% helix, 23% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C, D, F, d, f, g | ATP-dependent clp protease proteolytic subunit 2 (EC 3.4.21.92) | protein | 197 | 43% helix, 23% strand | P9WPC2 |
| B, b | ATP-dependent clp protease proteolytic subunit 2 (EC 3.4.21.92) | protein | 201 | 42% helix, 23% strand | P9WPC2 |
| E, e | ATP-dependent clp protease proteolytic subunit 2 (EC 3.4.21.92) | protein | 199 | 42% helix, 23% strand | P9WPC2 |
| G | ATP-dependent clp protease proteolytic subunit 2 (EC 3.4.21.92) | protein | 196 | 43% helix, 23% strand | P9WPC2 |
| H | ATP-dependent clp protease proteolytic subunit 1 (EC 3.4.21.92) | protein | 186 | 48% helix, 22% strand | P9WPC4 |
| I, J, K, L, M, j, k, l, m | ATP-dependent clp protease proteolytic subunit 1 (EC 3.4.21.92) | protein | 178 | 49% helix, 22% strand | P9WPC4 |
| N, n | ATP-dependent clp protease proteolytic subunit 1 (EC 3.4.21.92) | protein | 184 | 48% helix, 22% strand | P9WPC4 |
| a, c | ATP-dependent clp protease proteolytic subunit 2 (EC 3.4.21.92) | protein | 198 | 42% helix, 23% strand | P9WPC2 |
| h | ATP-dependent clp protease proteolytic subunit 1 (EC 3.4.21.92) | protein | 183 | 48% helix, 22% strand | P9WPC4 |
| i | ATP-dependent clp protease proteolytic subunit 1 (EC 3.4.21.92) | protein | 181 | 49% helix, 22% strand | P9WPC4 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 994 | 0.75 | 0.78 | 75 | empty |
| 2 | 626 | 0.74 | 0.81 | 90 | empty |
| 3 | 838 | 0.74 | 0.78 | 102 | empty |
| 4 | 840 | 0.72 | 0.77 | 95 | empty |
| 5 | 558 | 0.72 | 0.80 | 84 | empty |
Interfaces
79 interfaces between chains.
- A–G · 1894 Ų buried · 31 hydrogen bonds · protein-protein
- c–d · 1892 Ų buried · 24 hydrogen bonds · protein-protein
- a–b · 1888 Ų buried · 28 hydrogen bonds · protein-protein
- C–D · 1869 Ų buried · 25 hydrogen bonds · protein-protein
- d–e · 1834 Ų buried · 25 hydrogen bonds · protein-protein
Compared structures
- 5E0S · crystal structure of the active form of the proteolytic complex clpP1 and clpP2 · the same entry in another collection · chain K against K, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P9WPC2
- Every structure of UniProt P9WPC4
- Elsewhere: RCSB PDB 5E0S · PDBe 5E0S · UniProt P9WPC2 · UniProt P9WPC4
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