UniProt P9WPC4
ATP-dependent Clp protease proteolytic subunit 1 (P9WPC4)
ATP-dependent Clp protease proteolytic subunit 1 (UniProt P9WPC4), EC 3.4.21.92: 7 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 20 pockets. Binding sites, druggability and experiment against…
- UniProt
- P9WPC4
- Protein
- ATP-dependent Clp protease proteolytic subunit 1
- EC
- 3.4.21.92
- Experimental structures
- 7
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 20 · 1 record with a druggable one
Structures
8 records of P9WPC4 in the MolNFT archive: 7 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5DZK | Crystal structure of the active form of the proteolytic complex clpP1 and clpP2 | x-ray diffraction | H, I, J, K, L, M, N, h, i, j, k, l, m, n | — | — |
| 5DZK | Crystal structure of the active form of the proteolytic complex CLPP1 and CLPP2 | x-ray diffraction | H, I, J, K, L, M, N, h, i, j, k, l, m, n | — | — |
| 5E0S | crystal structure of the active form of the proteolytic complex clpP1 and clpP2 | x-ray diffraction | H, I, J, K, L, M, N, h, i, j, k, l, m, n | — | — |
| 5E0S | Crystal structure of the active form of the proteolytic complex CLPP1 and CLPP2 | x-ray diffraction | H, I, J, K, L, M, N, h, i, j, k, l, m, n | — | — |
| 6IW7 | structural insights into Mycobacterium tuberculosis ClpP1P2 inhibition by Cediranib: implications… | x-ray diffraction | B, D, I, K, M, N, G | AV3 | — |
| 6IW7 | Structural insights into mycobacterium tuberculosis CLPP1P2 inhibition by cediranib: implications… | x-ray diffraction | B, D, I, K, M, N, G | BEZ, AV3 | — |
| 7X8X | structural insights into Mycobacterium tuberculosis ClpP1P2 inhibition by Cediranib: implications… | x-ray diffraction | B, P, D, R, I, U, K, W, M, Y, N, Z, G, b | AI4 | 20 (best 0.74) |
| P9WPC4 | AlphaFold monomer V2.0 prediction for ATP-dependent clp protease proteolytic subunit 1 (P9WPC4) | predicted | A | — | — |
Ligands
Experiment against prediction
- 5DZK chain l against the predicted model P9WPC4: TM-score 0.99, RMSD 0.44 Å
- 5DZK chain l against the predicted model P9WPC4: TM-score 0.99, RMSD 0.44 Å
- 5DZK chain m against the predicted model P9WPC4: TM-score 0.99, RMSD 0.44 Å
- 5DZK chain m against the predicted model P9WPC4: TM-score 0.99, RMSD 0.44 Å
- 5E0S chain l against the predicted model P9WPC4: TM-score 0.99, RMSD 0.45 Å
- 5E0S chain l against the predicted model P9WPC4: TM-score 0.99, RMSD 0.45 Å
- 5DZK chain j against the predicted model P9WPC4: TM-score 0.99, RMSD 0.45 Å
- 5DZK chain j against the predicted model P9WPC4: TM-score 0.99, RMSD 0.45 Å
- 5E0S chain M against the predicted model P9WPC4: TM-score 0.99, RMSD 0.45 Å
- 5E0S chain M against the predicted model P9WPC4: TM-score 0.99, RMSD 0.45 Å
Elsewhere
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