MolNFT v1 · #11578 · protein

Are carboxy terminii of helices coded by the local sequence or by tertiary structure contacts

1JQU · Lysozyme: “Are carboxy terminii of helices coded by the local sequence or by tertiary structure contacts”. X-ray diffraction, 6 pockets (best druggability 0.64). MolNFT v1 #11578 on GenesisL1: 3D structure, binding sites and pockets…

PDB: 1JQU
Type: protein
Length: 656 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Lysozyme
EC: 3.2.1.17
UniProt: P00720
Pockets: 6 · best druggability 0.64

Structure

x-ray diffraction · 1 distinct chain · 62% helix, 9% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C, D	Lysozyme (EC 3.2.1.17)	protein	164	62% helix, 9% strand	P00720

Pockets

6 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	514	0.64	0.76	39	empty
2	178	0.50	0.77	19	empty
3	196	0.45	0.74	27	empty
4	138	0.42	0.75	23	empty
5	149	0.39	0.73	20	empty

Interfaces

3 interfaces between chains.

A–B · 817 Å² buried · 13 hydrogen bonds · protein-protein
B–D · 275 Å² buried · 3 hydrogen bonds · protein-protein
B–C · 126 Å² buried · 5 hydrogen bonds · protein-protein

Compared structures

1JQU · Are Carboxy Terminii of Helices Coded by the Local Sequence or by Tertiary Structure… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P00720
Elsewhere: RCSB PDB 1JQU · PDBe 1JQU · UniProt P00720

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