MolNFT v1 · #115469 · protein
Structure of aspergillus fumigatus ornithine hydroxylase (sida) mutant N323A bound to NADP and ornithine
5CKU · L-ornithine N(5)-monooxygenase: “Structure of aspergillus fumigatus ornithine hydroxylase (sida) mutant N323A bound to NADP and ornithine”. X-ray diffraction, 4 ligands (FAD, NAP, ORN), 4 pockets (best druggability 0.81). MolNFT v1…
- PDB
- 5CKU
- Type
- protein
- Length
- 451 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- L-ornithine N(5)-monooxygenase
- EC
- 1.14.13.196
- UniProt
- E9QYP0
- Ligands
- FAD, NAP, ORN, SO4
- Pockets
- 4 · best druggability 0.81
Structure
x-ray diffraction · 1 distinct chain · 32% helix, 21% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | L-ornithine N(5)-monooxygenase (EC 1.14.13.196) | protein | 451 | 32% helix, 21% strand | E9QYP0 |
Ligands and binding sites
- FAD · Flavin-adenine dinucleotide · ligand · chains A
- NAP · Nadp nicotinamide-adenine-dinucleotide phosphate · ligand · chains A
- ORN · L-ornithine · ligand · chains A
- SO4 · Sulfate ion · ion · 3 copies · chains A
- GOL · Glycerol · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1151 | 0.81 | 0.82 | 93 | FAD, NAP, ORN |
| 2 | 76 | 0.34 | 0.75 | 14 | empty |
| 3 | 67 | 0.32 | 0.75 | 20 | empty |
| 4 | 53 | 0.27 | 0.74 | 18 | empty |
Compared structures
- 5CKU · Structure of Aspergillus fumigatus ornithine hydroxylase (SidA) mutant N323A bound to… · the same entry in another collection · chain A against A, TM-score 1.00
- E9QYP0 · AlphaFold monomer V2.0 prediction for L-ornithine N(5)-monooxygenase (E9QYP0) · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt E9QYP0
- Elsewhere: RCSB PDB 5CKU · PDBe 5CKU · UniProt E9QYP0
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