MolNFT v1 · #115418 · protein
Crystal structure of the coiled coil of MYH7 residues 1526 to 1571 fused to GP7
5CJ1 · GP7-MYH7-(1526-1571) chimera protein: “Crystal structure of the coiled coil of MYH7 residues 1526 to 1571 fused to GP7”. X-ray diffraction, 2 pockets (best druggability 0.65). MolNFT v1 #115418 on GenesisL1: 3D structure, binding…
- PDB
- 5CJ1
- Type
- protein
- Length
- 780 residues
- Chains
- 8
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- GP7-MYH7-(1526-1571) chimera protein
- UniProt
- P13848, P12883
- Pockets
- 2 · best druggability 0.65
Structure
x-ray diffraction · 4 distinct chains · 89% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E | GP7-MYH7-(1526-1571) chimera protein | protein | 98 | 88% helix, 0% strand | P13848, P12883 |
| F | GP7-MYH7-(1526-1571) chimera protein | protein | 97 | 90% helix, 0% strand | P13848, P12883 |
| G | GP7-MYH7-(1526-1571) chimera protein | protein | 97 | 88% helix, 0% strand | P13848, P12883 |
| H | GP7-MYH7-(1526-1571) chimera protein | protein | 96 | 90% helix, 0% strand | P13848, P12883 |
Pockets
2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 255 | 0.65 | 0.82 | 30 | empty |
| 2 | 140 | 0.51 | 0.79 | 25 | empty |
Interfaces
12 interfaces between chains.
- G–H · 2334 Ų buried · 17 hydrogen bonds · protein-protein
- E–F · 2334 Ų buried · 17 hydrogen bonds · protein-protein
- A–B · 2296 Ų buried · 16 hydrogen bonds · protein-protein
- C–D · 2287 Ų buried · 16 hydrogen bonds · protein-protein
- B–C · 237 Ų buried · 2 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P13848
- Every structure of UniProt P12883
- Elsewhere: RCSB PDB 5CJ1 · PDBe 5CJ1 · UniProt P13848 · UniProt P12883
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