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Crystal structure of the coiled coil of MYH7 residues 1526 to 1571 fused to GP7

Analyse Crystal structure of the coiled coil of MYH7 residues 1526 to 1571 fused to GP7 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 5CJ1
Type: protein
Length: 780 residues
Chains: 8
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: GP7-MYH7-(1526-1571) chimera protein
UniProt: P13848, P12883
Pockets: 2 · best druggability 0.65

Structure

x-ray diffraction · 4 distinct chains · 89% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C, D, E	GP7-MYH7-(1526-1571) chimera protein	protein	98	88% helix, 0% strand	P13848, P12883
F	GP7-MYH7-(1526-1571) chimera protein	protein	97	90% helix, 0% strand	P13848, P12883
G	GP7-MYH7-(1526-1571) chimera protein	protein	97	88% helix, 0% strand	P13848, P12883
H	GP7-MYH7-(1526-1571) chimera protein	protein	96	90% helix, 0% strand	P13848, P12883

Pockets

2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	255	0.65	0.82	30	empty
2	140	0.51	0.79	25	empty

Interfaces

12 interfaces between chains.

G–H · 2334 Å² buried · 17 hydrogen bonds · protein-protein
E–F · 2334 Å² buried · 17 hydrogen bonds · protein-protein
A–B · 2296 Å² buried · 16 hydrogen bonds · protein-protein
C–D · 2287 Å² buried · 16 hydrogen bonds · protein-protein
B–C · 237 Å² buried · 2 hydrogen bonds · protein-protein

Compared structures

5CJ1 · Crystal structure of the coiled coil of MYH7 residues 1526 to 1571 fused to Gp7 · the same entry in another collection · chain H against H, TM-score 1.00
P12883 · AlphaFold monomer V2.0 prediction for myosin-7 (P12883) · a predicted model of the same protein · chain G against A, TM-score 0.78

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P13848
Every structure of UniProt P12883
Elsewhere: RCSB PDB 5CJ1 · PDBe 5CJ1 · UniProt P13848 · UniProt P12883

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