MolNFT v1 · #113944 · protein
Recombinant expression, purification and preliminary crystallographic studies of the mature form of human mitochondrial aspartate aminotransferase
5AX8 · Aspartate aminotransferase, mitochondrial: “Recombinant expression, purification and preliminary crystallographic studies of the mature form of human…”. X-ray diffraction, 20 pockets (best druggability 0.81). MolNFT v1 #113944 on…
- PDB
- 5AX8
- Type
- protein
- Length
- 1,604 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Aspartate aminotransferase, mitochondrial
- EC
- 2.6.1.1, 2.6.1.7
- UniProt
- P00505
- Pockets
- 20 · best druggability 0.81
Structure
x-ray diffraction · 1 distinct chain · 48% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D | Aspartate aminotransferase, mitochondrial (EC 2.6.1.1, 2.6.1.7) | protein | 401 | 48% helix, 15% strand | P00505 |
Pockets
20 pockets found on a 1 Å grid, 8 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1093 | 0.81 | 0.83 | 112 | empty |
| 2 | 603 | 0.73 | 0.80 | 57 | empty |
| 3 | 513 | 0.73 | 0.82 | 54 | empty |
| 4 | 586 | 0.71 | 0.80 | 71 | empty |
| 5 | 228 | 0.68 | 0.85 | 29 | empty |
Interfaces
5 interfaces between chains.
- B–D · 3440 Ų buried · 49 hydrogen bonds · protein-protein
- A–C · 3299 Ų buried · 41 hydrogen bonds · protein-protein
- A–B · 481 Ų buried · 4 hydrogen bonds · protein-protein
- A–D · 320 Ų buried · 0 hydrogen bonds · protein-protein
- C–D · 319 Ų buried · 2 hydrogen bonds · protein-protein
Compared structures
- 5AX8 · Recombinant expression, purification and preliminary crystallographic studies of the… · the same entry in another collection · chain D against D, TM-score 1.00
- P00505 · AlphaFold monomer V2.0 prediction for aspartate aminotransferase, mitochondrial (P00505) · a predicted model of the same protein · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P00505
- Elsewhere: RCSB PDB 5AX8 · PDBe 5AX8 · UniProt P00505
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