MolNFT v1 · #113316 · protein
Complex of D. melanogaster EIF4E with the 4E-binding protein mextli and cap analog
5ABU · Eukaryotic translation initiation factor 4E: “Complex of D. melanogaster EIF4E with the 4E-binding protein mextli and cap analog”. X-ray diffraction, 2 ligands (GTG, CL), 3 pockets (best druggability 0.40). MolNFT v1 #113316 on…
- PDB
- 5ABU
- Type
- protein
- Length
- 233 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Eukaryotic translation initiation factor 4E; 4E-binding protein mextli
- UniProt
- P48598, Q9VR35
- Ligands
- GTG, CL
- Pockets
- 3 · best druggability 0.40
Structure
x-ray diffraction · 2 distinct chains · 35% helix, 24% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Eukaryotic translation initiation factor 4E | protein | 175 | 30% helix, 31% strand | P48598 |
| B | 4E-binding protein mextli | protein | 58 | 50% helix, 2% strand | Q9VR35 |
Ligands and binding sites
- GTG · 7-methyl-guanosine-5'-triphosphate-5'-guanosine · ligand · chains A
- CL · Chloride ion · ion · chains B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 88 | 0.40 | 0.77 | 16 | empty |
| 2 | 123 | 0.39 | 0.74 | 29 | empty |
| 3 | 81 | 0.31 | 0.73 | 15 | empty |
Interfaces
1 interface between chains.
- A–B · 1577 Ų buried · 26 hydrogen bonds · protein-protein
Compared structures
- 5ABU · Complex of D. melanogaster eIF4E with the 4E-binding protein Mextli and cap analog · the same entry in another collection · chain A against A, TM-score 1.00
- P48598 · AlphaFold monomer V2.0 prediction for eukaryotic translation initiation factor 4E1… · a predicted model of the same protein · chain A against A, TM-score 0.99
- Q9VR35 · AlphaFold monomer V2.0 prediction for eukaryotic translation initiation factor 4E-binding… · a predicted model of the same protein · chain B against A, TM-score 0.71
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P48598
- Every structure of UniProt Q9VR35
- Elsewhere: RCSB PDB 5ABU · PDBe 5ABU · UniProt P48598 · UniProt Q9VR35
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