MolNFT v1 · #113120 · protein
Structure of mammalian EIF3 in the context of the 43S preinitiation complex
5A5U · Eukaryotic initiation factor 3: “Structure of mammalian EIF3 in the context of the 43S preinitiation complex”. Electron microscopy, 10 pockets (best druggability 0.79). MolNFT v1 #113120 on GenesisL1: 3D structure, binding sites and…
- PDB
- 5A5U
- Type
- protein
- Length
- 1,009 residues
- Chains
- 3
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Eukaryotic initiation factor 3; Eukaryotic translation initiation factor 3 subunit B…
- UniProt
- G1SZ03, P40217
- Pockets
- 10 · best druggability 0.79
Structure
electron microscopy · 3 distinct chains · 14% helix, 41% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Eukaryotic initiation factor 3 | protein | 54 | 91% helix, 0% strand | — |
| B | Eukaryotic translation initiation factor 3 subunit B | protein | 613 | 13% helix, 38% strand | G1SZ03 |
| I | Eukaryotic translation initiation factor 3 subunit I | protein | 342 | 4% helix, 51% strand | P40217 |
Pockets
10 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 783 | 0.79 | 0.82 | 70 | empty |
| 2 | 595 | 0.66 | 0.76 | 62 | empty |
| 3 | 373 | 0.59 | 0.76 | 37 | empty |
| 4 | 109 | 0.54 | 0.83 | 16 | empty |
| 5 | 397 | 0.54 | 0.73 | 50 | empty |
Interfaces
2 interfaces between chains.
- A–B · 1901 Ų buried · 39 hydrogen bonds · protein-protein
- B–I · 1595 Ų buried · 26 hydrogen bonds · protein-protein
Compared structures
- 5A5U · Structure of mammalian eIF3 in the context of the 43S preinitiation complex · the same entry in another collection · chain I against I, TM-score 1.00
- P40217 · AlphaFold monomer V2.0 prediction for eukaryotic translation initiation factor 3 subunit… · a predicted model of the same protein · chain I against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt G1SZ03
- Every structure of UniProt P40217
- Elsewhere: RCSB PDB 5A5U · PDBe 5A5U · UniProt G1SZ03 · UniProt P40217
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