Research workbench
Structure of mammalian EIF3 in the context of the 43S preinitiation complex
Analyse Structure of mammalian EIF3 in the context of the 43S preinitiation complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5A5U
- Type
- protein
- Length
- 1,009 residues
- Chains
- 3
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Eukaryotic initiation factor 3; Eukaryotic translation initiation factor 3 subunit B…
- UniProt
- G1SZ03, P40217
- Pockets
- 10 · best druggability 0.79
Structure
electron microscopy · 3 distinct chains · 14% helix, 41% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Eukaryotic initiation factor 3 | protein | 54 | 91% helix, 0% strand | — |
| B | Eukaryotic translation initiation factor 3 subunit B | protein | 613 | 13% helix, 38% strand | G1SZ03 |
| I | Eukaryotic translation initiation factor 3 subunit I | protein | 342 | 4% helix, 51% strand | P40217 |
Pockets
10 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 783 | 0.79 | 0.82 | 70 | empty |
| 2 | 595 | 0.66 | 0.76 | 62 | empty |
| 3 | 373 | 0.59 | 0.76 | 37 | empty |
| 4 | 109 | 0.54 | 0.83 | 16 | empty |
| 5 | 397 | 0.54 | 0.73 | 50 | empty |
Interfaces
2 interfaces between chains.
- A–B · 1901 Ų buried · 39 hydrogen bonds · protein-protein
- B–I · 1595 Ų buried · 26 hydrogen bonds · protein-protein
Compared structures
- 5A5U · Structure of mammalian eIF3 in the context of the 43S preinitiation complex · the same entry in another collection · chain I against I, TM-score 1.00
- P40217 · AlphaFold monomer V2.0 prediction for eukaryotic translation initiation factor 3 subunit… · a predicted model of the same protein · chain I against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt G1SZ03
- Every structure of UniProt P40217
- Elsewhere: RCSB PDB 5A5U · PDBe 5A5U · UniProt G1SZ03 · UniProt P40217
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