MolNFT v1 · #112880 · protein

Crystal structure of motavizumab and quaternary-specific rsv- neutralizing human antibody AM14 in complex with prefusion rsv F glycoprotein

4ZYP · Fusion glycoprotein F0,FIBRITIN: “Crystal structure of motavizumab and quaternary-specific rsv- neutralizing human antibody AM14 in complex…”. X-ray diffraction, 20 pockets (best druggability 0.84). MolNFT v1 #112880 on GenesisL1…

PDB: 4ZYP
Type: protein
Length: 3,906 residues
Chains: 15
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Fusion glycoprotein F0,FIBRITIN; Motavizumab antibody Fab heavy chain; Motavizumab…
UniProt: P03420, D9IEJ2
Pockets: 20 · best druggability 0.84

Structure

x-ray diffraction · 5 distinct chains · 15% helix, 44% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C	Fusion glycoprotein F0,FIBRITIN	protein	449	31% helix, 31% strand	P03420, D9IEJ2
J, K, N	Motavizumab antibody Fab heavy chain	protein	213	6% helix, 50% strand	—
L, M, O	Motavizumab antibody light chain	protein	211	5% helix, 49% strand	—
F, H, D	AM14 antibody Fab heavy chain	protein	216	7% helix, 53% strand	—
G, I, E	AM14 antibody light chain	protein	213	5% helix, 51% strand	—

Pockets

20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1108	0.84	0.85	82	empty
2	587	0.78	0.84	60	empty
3	1035	0.76	0.78	84	empty
4	1114	0.76	0.78	90	empty
5	1178	0.75	0.78	74	empty

Interfaces

33 interfaces between chains.

B–C · 2159 Å² buried · 13 hydrogen bonds · protein-protein
A–C · 2122 Å² buried · 13 hydrogen bonds · protein-protein
A–B · 2111 Å² buried · 12 hydrogen bonds · protein-protein
D–E · 1847 Å² buried · 14 hydrogen bonds · protein-protein
J–L · 1809 Å² buried · 13 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 48 disulfide (disulfide).

Compared structures

4ZYP · Crystal Structure of Motavizumab and Quaternary-Specific RSV-Neutralizing Human Antibody… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P03420
Every structure of UniProt D9IEJ2
Elsewhere: RCSB PDB 4ZYP · PDBe 4ZYP · UniProt P03420 · UniProt D9IEJ2

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