Research workbench
Crystal structure of motavizumab and quaternary-specific rsv- neutralizing human antibody AM14 in complex with prefusion rsv F glycoprotein
Analyse Crystal structure of motavizumab and quaternary-specific rsv- neutralizing… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4ZYP
- Type
- protein
- Length
- 3,906 residues
- Chains
- 15
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Fusion glycoprotein F0,FIBRITIN; Motavizumab antibody Fab heavy chain; Motavizumab…
- UniProt
- P03420, D9IEJ2
- Pockets
- 20 · best druggability 0.84
Structure
x-ray diffraction · 5 distinct chains · 15% helix, 44% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C | Fusion glycoprotein F0,FIBRITIN | protein | 449 | 31% helix, 31% strand | P03420, D9IEJ2 |
| J, K, N | Motavizumab antibody Fab heavy chain | protein | 213 | 6% helix, 50% strand | — |
| L, M, O | Motavizumab antibody light chain | protein | 211 | 5% helix, 49% strand | — |
| F, H, D | AM14 antibody Fab heavy chain | protein | 216 | 7% helix, 53% strand | — |
| G, I, E | AM14 antibody light chain | protein | 213 | 5% helix, 51% strand | — |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1108 | 0.84 | 0.85 | 82 | empty |
| 2 | 587 | 0.78 | 0.84 | 60 | empty |
| 3 | 1035 | 0.76 | 0.78 | 84 | empty |
| 4 | 1114 | 0.76 | 0.78 | 90 | empty |
| 5 | 1178 | 0.75 | 0.78 | 74 | empty |
Interfaces
33 interfaces between chains.
- B–C · 2159 Ų buried · 13 hydrogen bonds · protein-protein
- A–C · 2122 Ų buried · 13 hydrogen bonds · protein-protein
- A–B · 2111 Ų buried · 12 hydrogen bonds · protein-protein
- D–E · 1847 Ų buried · 14 hydrogen bonds · protein-protein
- J–L · 1809 Ų buried · 13 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 48 disulfide (disulfide).
Compared structures
- 4ZYP · Crystal Structure of Motavizumab and Quaternary-Specific RSV-Neutralizing Human Antibody… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P03420
- Every structure of UniProt D9IEJ2
- Elsewhere: RCSB PDB 4ZYP · PDBe 4ZYP · UniProt P03420 · UniProt D9IEJ2
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