MolNFT v1 · #112661 · protein
Structural complex of 5-aminofluorescein bound to the fto protein
4ZS3 · Alpha-ketoglutarate-dependent dioxygenase fto: “Structural complex of 5-aminofluorescein bound to the fto protein”. X-ray diffraction, 3 ligands (AKG, A4F, MN), 2 pockets (best druggability 0.69). MolNFT v1 #112661 on GenesisL1: 3D…
- PDB
- 4ZS3
- Type
- protein
- Length
- 432 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Alpha-ketoglutarate-dependent dioxygenase fto
- EC
- 1.14.11.-
- UniProt
- Q9C0B1
- Ligands
- AKG, A4F, MN
- Pockets
- 2 · best druggability 0.69
Structure
x-ray diffraction · 1 distinct chain · 42% helix, 21% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Alpha-ketoglutarate-dependent dioxygenase fto (EC 1.14.11.-) | protein | 432 | 42% helix, 21% strand | Q9C0B1 |
Ligands and binding sites
- AKG · 2-oxoglutaric acid · ligand · chains A
- A4F · 5-amino-2-(6-hydroxy-3-oxo-3H-xanthen-9-yl)benzoic acid · ligand · chains A
- MN · Manganese (II) ion · metal · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 328 | 0.69 | 0.82 | 40 | AKG, A4F, MN |
| 2 | 103 | 0.51 | 0.82 | 18 | empty |
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- 4ZS3 · Structural complex of 5-aminofluorescein bound to the FTO protein · the same entry in another collection · chain A against A, TM-score 1.00
- Q9C0B1 · AlphaFold monomer V2.0 prediction for alpha-ketoglutarate-dependent dioxygenase fto… · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9C0B1
- Elsewhere: RCSB PDB 4ZS3 · PDBe 4ZS3 · UniProt Q9C0B1
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